D
Daniel DiMaio
Researcher at Yale University
Publications - 159
Citations - 9478
Daniel DiMaio is an academic researcher from Yale University. The author has contributed to research in topics: Bovine papillomavirus & Transmembrane protein. The author has an hindex of 51, co-authored 150 publications receiving 8792 citations. Previous affiliations of Daniel DiMaio include Yale Cancer Center & Harvard University.
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Journal ArticleDOI
Senescence‐associated β‐galactosidase is lysosomal β‐galactosidase
Bo Yun Lee,Jung A. Han,Jun Sub Im,Amelia Morrone,Kimberly L. Johung,Edward C. Goodwin,Wim J. Kleijer,Daniel DiMaio,Eun Seong Hwang,Eun Seong Hwang +9 more
TL;DR: It is demonstrated here that SA‐β‐gal activity is expressed from GLB1, the gene encoding lysosomal β‐D‐galactosidase, the activity of which is typically measured at acidic pH 4.5.
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Identification of two distinct regulatory regions adjacent to the human β-interferon gene
TL;DR: To study the regulation of the human beta-interferon (beta-IFN) gene by poly(I)-poly(C), the expression of deletion mutants of the cloned gene introduced into mouse cells on a new bovine papilloma virus vector is analyzed.
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Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways
Edward C. Goodwin,Daniel DiMaio +1 more
TL;DR: This dynamic response strongly suggests that the p53 and Rb tumor suppressor pathways are intact in HeLa cells and that repression of HPV E6 and E7 mobilizes these pathways in an orderly fashion to deliver growth inhibitory signals to the cells.
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Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, Senescence, and Apoptosis in HeLa Cervical Carcinoma Cells
TL;DR: It is demonstrated that continuous expression of both the E6 and the E7 protein is required for optimal proliferation of cervical carcinoma cells and that the two viral proteins exert distinct effects on cell survival and proliferation.
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Human papillomavirus in cervical and head-and-neck cancer.
Amanda Psyrri,Daniel DiMaio +1 more
TL;DR: This Review summarizes the main events of the HPV life cycle, the functions of the viral proteins, and the implications of HPV infection on their hosts, with an emphasis on carcinogenic mechanisms and disease outcomes in head-and-neck cancer.