D
Daniel Duran-Sandoval
Researcher at Lille University of Science and Technology
Publications - 21
Citations - 2045
Daniel Duran-Sandoval is an academic researcher from Lille University of Science and Technology. The author has contributed to research in topics: Farnesoid X receptor & Insulin. The author has an hindex of 13, co-authored 18 publications receiving 1919 citations. Previous affiliations of Daniel Duran-Sandoval include Pasteur Institute & National Institutes of Health.
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Journal ArticleDOI
The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice
Bertrand Cariou,Bertrand Cariou,Bertrand Cariou,Kirsten Van Harmelen,Kirsten Van Harmelen,Kirsten Van Harmelen,Daniel Duran-Sandoval,Daniel Duran-Sandoval,Daniel Duran-Sandoval,Theo H. van Dijk,Aldo Grefhorst,Mouaadh Abdelkarim,Mouaadh Abdelkarim,Mouaadh Abdelkarim,Sandrine Caron,Sandrine Caron,Sandrine Caron,Gérard Torpier,Gérard Torpier,Gérard Torpier,Jean Charles Fruchart,Jean Charles Fruchart,Jean Charles Fruchart,Frank J. Gonzalez,Folkert Kuipers,Bart Staels,Bart Staels,Bart Staels +27 more
TL;DR: A novel role of FXR in the regulation of peripheral insulin sensitivity and adipocyte function is identified, which opens new perspectives for the treatment of type 2 diabetes.
Journal ArticleDOI
Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.
Thierry Claudel,Thierry Claudel,Yusuke Inoue,Olivier Barbier,Olivier Barbier,Daniel Duran-Sandoval,Daniel Duran-Sandoval,V. A. Kosykh,Jamila Fruchart,Jamila Fruchart,Jean-Charles Fruchart,Jean-Charles Fruchart,Frank J. Gonzalez,Bart Staels,Bart Staels +14 more
TL;DR: Bile acid and synthetic activators of the nuclear FXR are identified as negative regulators of Apo CIII expression, an effect that may contribute to the triglyceride-decreasing action of FXR agonists.
Journal ArticleDOI
Glucose regulates the expression of the farnesoid X receptor in liver.
Daniel Duran-Sandoval,Gisèle Mautino,Geneviève Martin,Frédéric Percevault,Olivier Barbier,Jean-Charles Fruchart,Folkert Kuipers,Bart Staels +7 more
TL;DR: It is demonstrated that FXR is decreased in animal models of diabetes and regulated by glucose likely via the pentose phosphate pathway, and expression of the FXR target genes, SHP and apolipoprotein C-III, were additively regulated by D-glucose and FXR ligands.
Journal ArticleDOI
The Farnesoid X Receptor Modulates Hepatic Carbohydrate Metabolism during the Fasting-Refeeding Transition
Daniel Duran-Sandoval,Bertrand Cariou,Frédéric Percevault,Nathalie Hennuyer,Aldo Grefhorst,Theo H. van Dijk,Frank J. Gonzalez,Jean Charles Fruchart,Folkert Kuipers,Bart Staels +9 more
TL;DR: A novel role for FXR is identified as a modulator of hepatic carbohydrate metabolism by identifying an accelerated response to high carbohydrate refeeding with an accelerated induction of glycolytic and lipogenic genes and a more pronounced repression of gluconeogenic genes.
Journal ArticleDOI
FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity.
Olivier Barbier,Inés Pineda Torra,Audrey Sirvent,Thierry Claudel,Christophe Blanquart,Daniel Duran-Sandoval,Folkert Kuipers,V. A. Kosykh,Jean-Charles Fruchart,Bart Staels +9 more
TL;DR: It is suggested that UGT2B4 gene induction by bile acids contributes to a feed-forward reduction of bile acid toxicity and a decrease of the activity of these biological FXR activators.