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Daniel E. Michele
Researcher at University of Michigan
Publications - 72
Citations - 5585
Daniel E. Michele is an academic researcher from University of Michigan. The author has contributed to research in topics: Myocyte & Muscular dystrophy. The author has an hindex of 33, co-authored 67 publications receiving 5168 citations. Previous affiliations of Daniel E. Michele include University of Iowa & Roy J. and Lucille A. Carver College of Medicine.
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Journal ArticleDOI
Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies
Daniel E. Michele,Rita Barresi,Motoi Kanagawa,Fumiaki Saito,Ronald D. Cohn,Jakob S. Satz,James Dollar,Ichizo Nishino,Richard I. Kelley,Hannu Somer,Volker Straub,Katherine D. Mathews,Steven A. Moore,Kevin P. Campbell +13 more
TL;DR: The results suggest that at least three distinct mammalian genes function within a convergent post-translational processing pathway during the biosynthesis of dystroglycan, and that abnormal dystoglycan–ligand interactions underlie the pathogenic mechanism of muscular dystrophy with brain abnormalities.
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Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy
Steven A. Moore,Fumiaki Saito,Jianguo Chen,Daniel E. Michele,Michael D. Henry,Albee Messing,Ronald D. Cohn,Susan E. Ross-Barta,Steve Westra,Roger A. Williamson,Toshinori Hoshi,Kevin P. Campbell +11 more
TL;DR: The hypothesis that defects in dystroglycan are central to the pathogenesis of structural and functional brain abnormalities seen in CMD is strongly supported.
Journal ArticleDOI
Dystrophin-Glycoprotein Complex: Post-translational Processing and Dystroglycan Function
TL;DR: The dystrophin-glycoprotein complex (DGC) is a multimeric transmembrane protein complex first isolated from skeletal muscle membranes and the central protein is dystroglycan, which is thought to contribute to the structural stability of the muscle cell membrane during cycles of contraction and relaxation.
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Dystrophic heart failure blocked by membrane sealant poloxamer
Soichiro Yasuda,DeWayne Townsend,Daniel E. Michele,Elizabeth G. Favre,Sharlene M. Day,Joseph M. Metzger +5 more
TL;DR: It is shown that intact, isolated dystrophin-deficient cardiac myocytes have reduced compliance and increased susceptibility to stretch-mediated calcium overload, leading to cell contracture and death, and that application of the membrane sealant poloxamer 188 corrects these defects in vitro.
Journal ArticleDOI
Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration.
Ronald D. Cohn,Michael D. Henry,Daniel E. Michele,Rita Barresi,Fumiaki Saito,Steven A. Moore,Jason D. Flanagan,Mark W. Skwarchuk,Michael E.C. Robbins,Jerry R. Mendell,Roger A. Williamson,Kevin P. Campbell +11 more
TL;DR: It is found that satellite cells, expressing dystroglycan, support continued efficient regeneration of skeletal muscle along with transient expression of dystrophin-glycoprotein complex in differentiated muscle and in regenerating muscle fibers in a mild form of human muscular dystrophy caused by disruption of posttranslational dystoglycan processing.