D
Daniel J. Whitcomb
Researcher at University of Bristol
Publications - 45
Citations - 3085
Daniel J. Whitcomb is an academic researcher from University of Bristol. The author has contributed to research in topics: Long-term potentiation & AMPA receptor. The author has an hindex of 22, co-authored 39 publications receiving 2661 citations. Previous affiliations of Daniel J. Whitcomb include Chonnam National University & University of Warwick.
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Journal ArticleDOI
Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization
Zheng Li,Jihoon Jo,Jie-Min Jia,Shih-Ching Lo,Daniel J. Whitcomb,Song Jiao,Kwangwook Cho,Morgan Sheng,Morgan Sheng +8 more
TL;DR: In this paper, it was shown that activation of caspase-3 via mitochondria is required for long-term depression and AMPA receptor internalization in hippocampal neurons.
Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization
Zheng Li,Jihoon Jo,Jie-Min Jia,Shih-Ching Lo,Daniel J. Whitcomb,Song Jiao,Kwangwook Cho,Morgan Sheng,Morgan Sheng +8 more
TL;DR: It is shown that activation of caspase-3 via mitochondria is required for LTD and AMPA receptor internalization in hippocampal neurons and indicates an unexpected causal link between the molecular mechanisms of apoptosis and LTD.
Journal ArticleDOI
Aβ 1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β
Jihoon Jo,Daniel J. Whitcomb,Kimberly Moore Olsen,Talitha L Kerrigan,Shih-Ching Lo,Gilles Bru-Mercier,Bryony A. Dickinson,Sarah Scullion,Morgan Sheng,Graham L. Collingridge,Kwangwook Cho +10 more
TL;DR: It is found that a signaling pathway involving caspase-3, Akt1 and glycogen synthase kinase 3β is an important mediator of this effect in rats and mice.
Journal ArticleDOI
Microtubule-associated protein tau is essential for long-term depression in the hippocampus
Tetsuya Kimura,Daniel J. Whitcomb,Jihoon Jo,Philip Regan,Thomas M. Piers,Seonghoo Heo,Christopher A. Brown,Tsutomu Hashikawa,Miyuki Murayama,Heon Seok,Ioannis Sotiropoulos,Ioannis Sotiropoulos,Eunjoon Kim,Graham L. Collingridge,Akihiko Takashima,Kwangwook Cho +15 more
TL;DR: It is found that the induction of LTD is associated with the glycogen synthase kinase-3-mediated phosphorylation of tau, which demonstrates that tau has a critical physiological function in LTD.
Journal ArticleDOI
Tau phosphorylation at serine 396 residue is required for hippocampal LTD
Philip Regan,Thomas M. Piers,Jee-Hyun Yi,Dong-Hyun Kim,Seonghoo Huh,Se Jin Park,Jong Hoon Ryu,Daniel J. Whitcomb,Kwangwook Cho +8 more
TL;DR: It is found that an AMPA receptor internalization mechanism is impaired in tau KO mice, and that LTD causes specific phosphorylation at the serine 396 and 404 residues of tau.