C
Cyril Gaudin
Researcher at Lille University of Science and Technology
Publications - 10
Citations - 686
Cyril Gaudin is an academic researcher from Lille University of Science and Technology. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 4, co-authored 6 publications receiving 544 citations.
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Journal ArticleDOI
Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.
Timothy M Walker,Thomas Kohl,Shaheed V. Omar,Jessica Hedge,Carlos del Ojo Elias,Phelim Bradley,Zamin Iqbal,Silke Feuerriegel,Katherine E. Niehaus,Daniel J. Wilson,David A. Clifton,Georgia Kapatai,Camilla L. C. Ip,Rory Bowden,Francis Drobniewski,Francis Drobniewski,Caroline Allix-Béguec,Cyril Gaudin,Julian Parkhill,Roland Diel,Philip Supply,Philip Supply,Derrick W. Crook,E. Grace Smith,A. Sarah Walker,Nazir Ahmed Ismail,Stefan Niemann,Tim E. A. Peto +27 more
TL;DR: A broad catalogue of genetic mutations enable data from whole-genome sequencing to be used clinically to predict drug resistance, drug susceptibility, or to identify drug phenotypes that cannot yet be genetically predicted.
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Outbreak of multidrug-resistant tuberculosis in South Africa undetected by WHO-endorsed commercial tests: an observational study.
Ndivhuho Agnes Makhado,Edith Matabane,Mauro Faccin,Claire Pinçon,Agathe Jouet,Fairouz Boutachkourt,Léonie Goeminne,Cyril Gaudin,Gugu Maphalala,Patrick Beckert,Stefan Niemann,Jean-Charles Delvenne,Jean-Charles Delvenne,Michel Delmée,Lufuno Razwiedani,Maphoshane Nchabeleng,Maphoshane Nchabeleng,Philip Supply,Bouke C. de Jong,Emmanuel André +19 more
TL;DR: Consistent with Deeplex-MycTB genotypic profiles, whole-genome sequencing revealed concurrent silent spread in South Africa of a MDR tuberculosis strain lineage extending from the eSwatini outbreak and at least another independently emerged Ile491Phe-bearing lineage.
Journal ArticleDOI
How Well Do Routine Molecular Diagnostics Detect Rifampin Heteroresistance in Mycobacterium tuberculosis
Kamela C. S. Ng,Kamela C. S. Ng,Philip Supply,Frank Cobelens,Cyril Gaudin,Julian Gonzalez-Martin,Bouke C. de Jong,Leen Rigouts,Leen Rigouts +8 more
TL;DR: The findings inform end users that the threshold for reporting resistance in the case of rifampin heteroresistance is the highest for Classic Xpert and Ultra to resolve phenotypic and genotypic discordant rifampsin-resistant TB results.
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Drug-Resistant Tuberculosis, Lebanon, 2016 - 2017.
Salam El Achkar,Christine Demanche,Marwan Osman,Rayane Rafei,Mohamad Bachar Ismail,Hiam Yaacoub,Claire Pinçon,Stéphanie Duthoy,Frédérique De Matos,Cyril Gaudin,Alberto Trovato,Daniela Maria Cirillo,Monzer Hamze,Philip Supply +13 more
TL;DR: Enhanced diagnostics, particularly in major destinations for refugees, asylum seekers, and migrant workers, can inform treatment decisions and may help prevent the spread of drug-resistant TB.
Journal ArticleDOI
Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis
Matthias Merker,Jean-Philippe Rasigade,Maxime Barbier,Helen Cox,Silke Feuerriegel,Thomas Kohl,Egor Shitikov,Kadri Klaos,Cyril Gaudin,Rudy Antoine,Roland Diel,Sonia Borrell,Sebastien Gagneux,Vladyslav Nikolayevskyy,Sönke Andres,Valeriu Crudu,Philip Supply,Stefan Niemann,Thierry Wirth +18 more
TL;DR: In this paper , the authors determined factors underlying the emergence and epidemic spread of the W148 clade by genome sequencing and Bayesian demogenetic analyses of 720 isolates from 23 countries.