Daniel R. Beisner

TL;DR: It is suggested that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals.

TL;DR: It is demonstrated that deficiency in Foxo3 resulted in greater expansion of T cell populations after viral infection, and this exaggerated expansion was not T cell intrinsic, but was caused by the enhanced capacity ofFoxo3-deficient dendritic cells to sustain T cell viability by producing more interleukin 6.

TL;DR: The activation of NF-κB or IFN regulatory factor 3 was found to be unaffected by the loss of caspase-8, implicating it in a novel pathway important for some forms of innate immunity mediated by B cells.

TL;DR: The selective genetic ablation of caspase-8, NFκB, and Ripk1, reveals two forms of cell death that can regulate virus-specific T cell expansion.

TL;DR: Results show that, in a highly regulated fashion, FADD, and most likely caspases, can transduce either a signal for survival or one that leads directly to apoptosis and that the balance between these opposing outcomes is crucial to adaptive immunity.