D
Daniel R. Beisner
Researcher at University of California, San Diego
Publications - 7
Citations - 1085
Daniel R. Beisner is an academic researcher from University of California, San Diego. The author has contributed to research in topics: T cell & Interleukin 3. The author has an hindex of 6, co-authored 7 publications receiving 1013 citations. Previous affiliations of Daniel R. Beisner include Novartis.
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Journal ArticleDOI
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
Yann M. Kerdiles,Daniel R. Beisner,Roberto Tinoco,Anne Dejean,Diego H. Castrillon,Ronald A. DePinho,Stephen M. Hedrick +6 more
TL;DR: It is suggested that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals.
Journal ArticleDOI
Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells
Anne Dejean,Daniel R. Beisner,Daniel R. Beisner,Irene L. Ch’en,Yann M. Kerdiles,Anna Babour,Karen C. Arden,Diego H. Castrillon,Diego H. Castrillon,Diego H. Castrillon,Ronald A. DePinho,Stephen M. Hedrick +11 more
TL;DR: It is demonstrated that deficiency in Foxo3 resulted in greater expansion of T cell populations after viral infection, and this exaggerated expansion was not T cell intrinsic, but was caused by the enhanced capacity ofFoxo3-deficient dendritic cells to sustain T cell viability by producing more interleukin 6.
Journal ArticleDOI
Cutting Edge: Innate Immunity Conferred by B Cells Is Regulated by Caspase-8
TL;DR: The activation of NF-κB or IFN regulatory factor 3 was found to be unaffected by the loss of caspase-8, implicating it in a novel pathway important for some forms of innate immunity mediated by B cells.
Journal ArticleDOI
Antigen-mediated T cell expansion regulated by parallel pathways of death
Irene L. Ch’en,Daniel R. Beisner,Alexei Degterev,Candace Lynch,Junying Yuan,Alexander Hoffmann,Stephen M. Hedrick +6 more
TL;DR: The selective genetic ablation of caspase-8, NFκB, and Ripk1, reveals two forms of cell death that can regulate virus-specific T cell expansion.
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The requirements for Fas-associated death domain signaling in mature T cell activation and survival.
TL;DR: Results show that, in a highly regulated fashion, FADD, and most likely caspases, can transduce either a signal for survival or one that leads directly to apoptosis and that the balance between these opposing outcomes is crucial to adaptive immunity.