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Daniel S. Lark
Researcher at Colorado State University
Publications - 31
Citations - 872
Daniel S. Lark is an academic researcher from Colorado State University. The author has contributed to research in topics: Skeletal muscle & Mitochondrion. The author has an hindex of 12, co-authored 27 publications receiving 709 citations. Previous affiliations of Daniel S. Lark include Vanderbilt University & East Carolina University.
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Journal ArticleDOI
Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle
Christopher G. R. Perry,Daniel A. Kane,Chien-Te Lin,Rachel Kozy,Brook L. Cathey,Daniel S. Lark,Constance L. Kane,Patricia Brophy,Timothy P. Gavin,Ethan J. Anderson,P. Darrell Neufer +10 more
TL;DR: It is demonstrated that the sensitivity of muscle to ADP varies over a wide range in relation to contractile state and cellular energy charge, providing evidence that enzymatic coupling of energy transfer within skeletal muscle becomes more efficient in the working state.
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Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.
Kelsey H. Fisher-Wellman,Chien-Te Lin,Terence E. Ryan,Lauren Reese,Laura A. A. Gilliam,Brook L. Cathey,Daniel S. Lark,Cody D. Smith,Deborah M. Muoio,P. Darrell Neufer +9 more
TL;DR: The integration of redox sensing of metabolic balance with compensatory changes in energy expenditure provides a potential mechanism by which cellular redox homoeostasis is maintained and body weight is defended during periods of positive and negative energy balance.
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Mitochondrial Glutathione Depletion Reveals a Novel Role for the Pyruvate Dehydrogenase Complex as a Key H2O2-emitting Source Under Conditions of Nutrient Overload
Kelsey H. Fisher-Wellman,Laura A. A. Gilliam,Chien-Te Lin,Brook L. Cathey,Daniel S. Lark,P. Darrell Neufer +5 more
TL;DR: Findings reveal the pyruvate dehydrogenase complex (PDC) as a potential major site of H2O2 production that is extremely sensitive to mitochondrial glutathione redox status.
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Do Fish Oil Omega-3 Fatty Acids Enhance Antioxidant Capacity and Mitochondrial Fatty Acid Oxidation in Human Atrial Myocardium via PPARγ Activation?
Ethan J. Anderson,Kathleen Thayne,Mitchel Harris,Saame Raza Shaikh,Timothy M. Darden,Daniel S. Lark,John Mark Williams,W. Randolph Chitwood,Alan P. Kypson,Evelio Rodriguez +9 more
TL;DR: It is hypothesized that PPARγ activation is a mechanism by which fish oil n-3 PUFAs enhance mitochondrial fatty acid oxidation and antioxidant capacity in human atrial myocardium, and that this preoperative therapeutic regimen may be optimal for mitigating oxidative/inflammatory stress associated with cardiac surgery.
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Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle
Christopher G. R. Perry,Daniel A. Kane,Eric A.F. Herbst,Kazutaka Mukai,Daniel S. Lark,David C. Wright,George J. F. Heigenhauser,P. Darrell Neufer,Lawrence L. Spriet,Graham P. Holloway +9 more
TL;DR: This shows miCK activity is increased post‐exercise, especially during contraction in PmFBs, and suggests exercise regulates phosphate shuttling, which would improve maintenance of energy homeostasis during contraction.