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Saame Raza Shaikh
Researcher at University of North Carolina at Chapel Hill
Publications - 143
Citations - 5628
Saame Raza Shaikh is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Polyunsaturated fatty acid & Docosahexaenoic acid. The author has an hindex of 37, co-authored 118 publications receiving 4652 citations. Previous affiliations of Saame Raza Shaikh include East Carolina University & Indiana University – Purdue University Indianapolis.
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Journal ArticleDOI
Expert consensus document: Mitochondrial function as a therapeutic target in heart failure
David Brown,Justin B. Perry,Mitchell E. Allen,Hani N. Sabbah,Hani N. Sabbah,Brian L. Stauffer,Saame Raza Shaikh,John G.F. Cleland,Wilson S. Colucci,Javed Butler,Adriaan A. Voors,Stefan D. Anker,Bertram Pitt,Bertram Pitt,Burkert Pieske,Gerasimos Filippatos,Stephen J. Greene,Mihai Gheorghiade +17 more
TL;DR: In this article, insights into the mechanisms of mitochondrial dysfunction in heart failure are presented, along with an overview of emerging treatments with the potential to improve the function of the failing heart by targeting mitochondria.
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Docosahexaenoic acid affects cell signaling by altering lipid rafts.
TL;DR: The uptake of DHA into brain phosphatidylethanolamines and the subsequent exclusion of cholesterol from the DHA-rich membranes is reported and a proposal of how DHA incorporation into membranes may control cell biochemistry and physiology is proposed.
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Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation
Saame Raza Shaikh,Michael Edidin +1 more
TL;DR: This review uses data from in vitro and in vivo experiments to make the case that the immunosuppressive effects of PUFAs begin with membrane incorporation and modulation of lipid-protein lateral organization.
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How polyunsaturated fatty acids modify molecular organization in membranes: insight from NMR studies of model systems.
TL;DR: Overall, the notion that NMR experiments on model membranes suggest a complex model by which n-3 PUFA reorganize lipid microdomains in vivo is highlighted.
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Docosahexaenoic and eicosapentaenoic acids segregate differently between raft and nonraft domains.
Justin A. Williams,Shawn E. Batten,Mitchel Harris,Benjamin Drew Rockett,Saame Raza Shaikh,William Stillwell,Stephen R. Wassall +6 more
TL;DR: It is proposed that DHA may be the more bioactive component of fish oil that serves to disrupt lipid raft domain organization, and represents an evolution in the view of how PUFA remodel membrane architecture.