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Daniel Spencer
Researcher at University of Southampton
Publications - 40
Citations - 1111
Daniel Spencer is an academic researcher from University of Southampton. The author has contributed to research in topics: Electrical impedance & Glycan. The author has an hindex of 17, co-authored 34 publications receiving 758 citations.
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Journal ArticleDOI
Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies.
Laura K. Pritchard,Daniel Spencer,Louise Royle,Camille Bonomelli,Gemma E. Seabright,Anna-Janina Behrens,Daniel W. Kulp,Sergey Menis,Stefanie A. Krumm,D. Cameron Dunlop,Daniel J. Crispin,Thomas A. Bowden,Christopher N. Scanlan,Andrew B. Ward,William R. Schief,William R. Schief,Katie J. Doores,Max Crispin +17 more
TL;DR: The contribution of individual glycosylation sites to formation of this so-called intrinsic mannose patch is investigated and it is shown that structural changes are largely tolerated by a panel of glycan-dependent bnAbs targeting these regions, indicating a degree of plasticity in their recognition.
Journal ArticleDOI
A fast impedance-based antimicrobial susceptibility test.
Daniel Spencer,Teagan F. Paton,Kieran T. Mulroney,Timothy J. J. Inglis,J. Mark Sutton,Hywel Morgan +5 more
TL;DR: A label-free AST that can deliver results within an hour, using an actively dividing culture as starting material is described, consistent with those obtained by classical broth microdilution assays for a range of antibiotics and bacterial species.
Journal ArticleDOI
Positional dependence of particles in microfludic impedance cytometry
Daniel Spencer,Hywel Morgan +1 more
TL;DR: It is demonstrated that for a nominal 40 μm × 40μm channel, the impedance signal is independent of position over the majority of the channel area, but shows large experimentally verifiable variation at extreme positions.
Journal ArticleDOI
High-Speed Single-Cell Dielectric Spectroscopy.
Daniel Spencer,Hywel Morgan +1 more
TL;DR: A new approach is demonstrated that uses multi-frequency impedance measurements to determine the complete intrinsic electrical properties of thousands of single cells at high throughput.
Journal ArticleDOI
High accuracy particle analysis using sheathless microfluidic impedance cytometry
TL;DR: A new design of microfluidic impedance cytometer enabling accurate characterization of particles without the need for focusing is described, giving excellent coefficient of variation in (electrical) radius of particles of 1% for a sheathless configuration.