Daniel Wolozny

TL;DR: This first large-scale proteomic analysis of Chinese hamster ovary (CHO) cells will enhance the knowledge base about CHO capabilities for recombinant expression and provide information useful in cell engineering efforts aimed at modifying CHO cellular functions.

TL;DR: An overview of sialic acids, potassium and sodium channel function, and the impact of sIALylation on channel activation and deactivation is provided.

TL;DR: The MAM is a critical cell-signaling junction whereby Bcl-xL dynamically interacts with IP3R3 to coordinate mitochondrial Ca2+ transfer and alters cellular metabolism in order to increase the cells’ bioenergetic capacity, particularly during periods of stress.

TL;DR: A publically accessible web-based tool called GO-CHO is created to functionally categorize proteins found in CHO-SO and identify enriched molecular functions, biological processes, and cellular components that will enable the CHO community to rapidly identify high-abundance HCPs in cultures and therefore help assess process and purification methods used in the production of biologic drugs.

TL;DR: This study reviews 15 different publicly available databases of glycosylation related databases and identifies their key elements so that users can identify the most applicable platform for their analytical needs to characterize and categorize glycoproteins and glycans better for biomedical research.