D
Daniela Brodbeck
Researcher at Friedrich Miescher Institute for Biomedical Research
Publications - 5
Citations - 1165
Daniela Brodbeck is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Protein kinase A & Phosphorylation. The author has an hindex of 5, co-authored 5 publications receiving 1126 citations.
Papers
More filters
Journal ArticleDOI
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis.
Oliver Tschopp,Zhong Zhou Yang,Daniela Brodbeck,Bettina Dummler,Maja Hemmings-Mieszczak,Takashi Watanabe,Thomas Michaelis,Jens Frahm,Brian A. Hemmings +8 more
TL;DR: The results provide novel insights into the physiological role of PKBγ and suggest a crucial role in postnatal brain development.
Journal ArticleDOI
Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth
Zhong-Zhou Yang,Oliver Tschopp,Maja Hemmings-Mieszczak,Jianhua Feng,Daniela Brodbeck,Elias Perentes,Brian A. Hemmings +6 more
TL;DR: It is shown that PKBα is widely expressed in placenta including all types of trophoblast and vascular endothelial cells and shows significant hypotrophy, with marked reduction of the decidual basalis and nearly complete loss of glycogen-containing cells in the spongiotrophoblast, and exhibit decreased vascularization.
Journal ArticleDOI
A Human Protein Kinase Bγ with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain
TL;DR: Cloned human protein kinase Bγ (PKBγ) is found that it contains two regulatory phosphorylation sites, Thr305 and Ser472, which correspond to Thr308 and Ser473 of PKBα, which differs significantly from the previously published rat PKBγ.
Journal ArticleDOI
Mechanism of Protein Kinase B Activation by Insulin/Insulin-Like Growth Factor-1 Revealed by Specific Inhibitors of Phosphoinositide 3-Kinase—Significance for Diabetes and Cancer
Ivana Galetic,Mirjana Andjelkovic,Roger Meier,Daniela Brodbeck,Jongsun Park,Brian A. Hemmings +5 more
TL;DR: Stimulation of PKB activity protects cells from apoptosis by phosphorylation and inactivation of the pro-apoptotic protein BAD, which could explain why PKB is overexpressed in some ovarian, breast, and pancreatic carcinomas.
Journal ArticleDOI
Two Splice Variants of Protein Kinase Bγ Have Different Regulatory Capacity Depending on the Presence or Absence of the Regulatory Phosphorylation Site Serine 472 in the Carboxyl-terminal Hydrophobic Domain
TL;DR: Results suggest that phosphorylation of the hydrophobic motif at the extreme C terminus of PKBγ may facilitate translocation of the kinase to the membrane and/or its phosphorylated on the activation loop site by phosphoinositide-dependent protein kinase-1.