O
Oliver Tschopp
Researcher at University of Zurich
Publications - 46
Citations - 2859
Oliver Tschopp is an academic researcher from University of Zurich. The author has contributed to research in topics: Protein kinase B & Acromegaly. The author has an hindex of 18, co-authored 45 publications receiving 2518 citations. Previous affiliations of Oliver Tschopp include Friedrich Miescher Institute for Biomedical Research & University of Naples Federico II.
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Journal ArticleDOI
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis.
Oliver Tschopp,Zhong Zhou Yang,Daniela Brodbeck,Bettina Dummler,Maja Hemmings-Mieszczak,Takashi Watanabe,Thomas Michaelis,Jens Frahm,Brian A. Hemmings +8 more
TL;DR: The results provide novel insights into the physiological role of PKBγ and suggest a crucial role in postnatal brain development.
Journal ArticleDOI
Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth
Zhong-Zhou Yang,Oliver Tschopp,Maja Hemmings-Mieszczak,Jianhua Feng,Daniela Brodbeck,Elias Perentes,Brian A. Hemmings +6 more
TL;DR: It is shown that PKBα is widely expressed in placenta including all types of trophoblast and vascular endothelial cells and shows significant hypotrophy, with marked reduction of the decidual basalis and nearly complete loss of glycogen-containing cells in the spongiotrophoblast, and exhibit decreased vascularization.
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PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.
TL;DR: The signal transduction mechanisms of PI3K/AKT, MAPK and AMPK and their roles in glucose homeostasis are reviewed and discussed, and current clinical implications are discussed.
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Physiological functions of protein kinase B/Akt.
TL;DR: The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity of information obtained from cell culture experiments.
Journal ArticleDOI
Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies
Bettina Dummler,Oliver Tschopp,Debby Hynx,Zhong-Zhou Yang,Stephan Dirnhofer,Brian A. Hemmings +5 more
TL;DR: A single functional allele of Akt1 appears to be sufficient for successful embryonic development and postnatal survival, in sharp contrast to the previously described lethal phenotypes ofAkt1−/−Akt2−/+Akt3+/− mice.