Elias Perentes

TL;DR: Urinary Kim-1 measurements may facilitate sensitive, specific and accurate prediction of human nephrotoxicity in preclinical drug screens, which should enable early identification and elimination of compounds that are potentiallyNephrotoxic.

TL;DR: It is shown that PKBα is widely expressed in placenta including all types of trophoblast and vascular endothelial cells and shows significant hypotrophy, with marked reduction of the decidual basalis and nearly complete loss of glycogen-containing cells in the spongiotrophoblast, and exhibit decreased vascularization.

TL;DR: Gene and protein expression analysis, in-situ hybridization and immunohistochemistry provide mechanistic evidence to support the use of four previously described nephrotoxicity markers for detecting kidney injury to guide regulatory decision making in drug development.

TL;DR: Because class III β-tubulin is present in neoplastic but not in normal differentiated glial cells, the elucidation of molecular mechanisms responsible for the altered expression of this isotype may provide critical insights into the dynamics of the microtubule cytoskeleton in the growth and progression of gliomas.

TL;DR: Increased immunoreactivity for Ki-67 epitopes (Ki-67 LI higher than 4) was noted in a number of meningiomas, astrocytomas, ependymomas, oligodendrogliomas and paragangliomas, contrasting with their benign histological features.