Daniela M. Menichella

TL;DR: Evidence is provided that gap-junction communication is crucial for normal central myelination in oligodendrocytes and that animals lacking both connexins die by postnatal week 6 from profound abnormalities in central myelin.

TL;DR: This study, which is to the authors' knowledge, the largest trial of CIDP to date and the first to study two administrations of immunoglobulins and two doses, showed that both doses of SCIg IgPro20 were efficacious and well tolerated, suggesting thatSCIg can be used as a maintenance treatment for C IDP.

TL;DR: Examination of the effect of neuronal activity on the appearance of vacuoles and genetic complementation implicate oligodendrocytes and their connexins as having critical roles in the buffering of K+ released during neuronal activity.

TL;DR: It is found that heterozygous P0 knockout mice develop a neuropathy that resembles CIDP, and morphological analysis of affected nerves reveals severe and selective demyelination of motor fibers, focal regions of demyElination, and inflammatory cells, which suggest that immune-mediated mechanisms may contribute to the pathogenesis of the neuropathy in P0+/- mice.

TL;DR: A model wherein microRNAs are critical for downregulation of antecedent programs of gene expression is posited in SC differentiation, particularly relevant in the key developmental transition from a promyelinating to myelinating SC.