David Walk

TL;DR: Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia and Charcot-Marie-Tooth type 2.

TL;DR: Quantitative sensory testing (QST) is a psychophysical method used to quantify somatosensory function in response to controlled stimuli in healthy subjects and patients as discussed by the authors, which has not gained a large acceptance among clinicians for many reasons, and in significant part because of the lack of information about standards for performing QST, its potential utility and interpretation of results.

TL;DR: In 3 of the 6 subjects, there were significant reductions in mean discharge rate of motor units in the paretic muscle, which could potentially alter the precise match of motoneuron properties to the mechanical properties of the innerved muscle fibers, and reduce the efficiency of muscle contraction.

TL;DR: This study, which is to the authors' knowledge, the largest trial of CIDP to date and the first to study two administrations of immunoglobulins and two doses, showed that both doses of SCIg IgPro20 were efficacious and well tolerated, suggesting thatSCIg can be used as a maintenance treatment for C IDP.

TL;DR: The results help predict the long-term safety of NGX-4010 applications in patients by evaluating the effect of a single 60-minute application on ENF density and QST in healthy volunteers followed for 24 weeks.