S
Shahram Attarian
Researcher at Aix-Marseille University
Publications - 207
Citations - 7071
Shahram Attarian is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 34, co-authored 165 publications receiving 5043 citations. Previous affiliations of Shahram Attarian include French Institute of Health and Medical Research.
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Journal ArticleDOI
Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
David Adams,Alejandra González-Duarte,William O'Riordan,Chih-Chao Yang,Mitsuharu Ueda,Arnt V. Kristen,Ivailo Tournev,Hartmut Schmidt,Teresa Coelho,John L. Berk,Kon Ping Lin,Giuseppe Vita,Shahram Attarian,Violaine Planté-Bordeneuve,Michelle M. Mezei,Josep M. Campistol,Juan Buades,Thomas H. Brannagan,Byoung Joon Kim,Jeeyoung Oh,Yesim Parman,Yoshiki Sekijima,Philip N. Hawkins,Scott D. Solomon,Michael Polydefkis,Peter J. Dyck,Pritesh Gandhi,Sunita Goyal,Jihong Chen,Andrew Strahs,Saraswathy V. Nochur,Marianne T. Sweetser,Pushkal Garg,Pushkal Garg,Akshay Vaishnaw,Akshay Vaishnaw,Jared Gollob,Ole B. Suhr +37 more
TL;DR: Patisiran improved multiple clinical manifestations of hereditary transthyretin amyloidosis with polyneuropathy and showed an effect on gait speed and modified BMI.
Journal ArticleDOI
Phenotypic Study in 40 Patients With Dysferlin Gene Mutations: High Frequency of Atypical Phenotypes
Karine Nguyen,Guillaume Bassez,Martin Krahn,Rafaëlle Bernard,Pascal Laforêt,Véronique Labelle,Jon Andoni Urtizberea,Dominique Figarella-Branger,Norma B. Romero,Shahram Attarian,Jean Pouget,Nicolas Lévy,Bruno Eymard +12 more
TL;DR: In addition to typical Miyoshi myopathy and limb-girdle muscular dystrophy type 2B, dysferlinopathies are a clinically heterogeneous group of disorders ranging from asymptomatism to severe functional disability.
Journal ArticleDOI
MUSK, a new target for mutations causing congenital myasthenic syndrome
Frédéric Chevessier,Brice Faraut,Aymeric Ravel-Chapuis,Pascale Richard,K. Gaudon,S. Bauche,Cassandra Prioleau,Ruth Herbst,Evelyne Goillot,Christine Ioos,Jean-Philippe Azulay,Shahram Attarian,Jean-Paul Leroy,Emmanuel Fournier,Claire Legay,Laurent Schaeffer,Jeanine Koenig,Michel Fardeau,Bruno Eymard,Jean Pouget,Daniel Hantaï +20 more
TL;DR: Results strongly suggest that the missense mutation, in the presence of a null mutation on the other allele, is responsible for the dramatic synaptic changes observed in the patient.
Journal ArticleDOI
Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial
Ivo N. van Schaik,Vera Bril,Nan van Geloven,Hans-Peter Hartung,Richard A. Lewis,Gen Sobue,John-Philip Lawo,Michaela Praus,Orell Mielke,Billie L. Durn,David R. Cornblath,Ingemar S. J. Merkies,A. Sabet,K. George,Leslie Roberts,R. Carne,Stefan Blum,Robert D. Henderson,P. Van Damme,J. Demeestere,S. Larue,C. D'Amour,Vera Bril,Ari Breiner,P. Kunc,Martin Vališ,J. Sussova,T. Kalous,R. Talab,M. Bednar,Toomas Toomsoo,Inna Rubanovits,Katrin Gross-Paju,U. Sorro,M. Saarela,Mari Auranen,Jean Pouget,Shahram Attarian,G. Le Masson,Anne-Cécile Wielanek-Bachelet,Claude Desnuelle,Emilien Delmont,Pierre Clavelou,D. Aufauvre,Jens Ejbye Schmidt,J. Zschuentssch,Claudia Sommer,D. Kramer,Olaf Hoffmann,C. Goerlitz,J. Haas,M. Chatzopoulos,R. Yoon,R. Gold,P. Berlit,A. Jaspert-Grehl,D. Liebetanz,A. Kutschenko,Martin Stangel,C. Trebst,P. Baum,Florian Then Bergh,Juliane Klehmet,Andreas Meisel,Fabian Klostermann,J. Oechtering,Helmar C. Lehmann,Michael Schroeter,Tim Hagenacker,D. Mueller,Anne D. Sperfeld,F. Bethke,Vivian E. Drory,A. Algom,David Yarnitsky,B. Murinson,A. Di Muzio,F. Ciccocioppo,Sandro Sorbi,Sabrina Matà,Angelo Schenone,Marina Grandis,Giuseppe Lauria,Daniele Cazzato,Giovanni Antonini,Stefania Morino,Dario Cocito,M. Zibetti,Takanori Yokota,Takuya Ohkubo,Takashi Kanda,M. Kawai,Kenichi Kaida,H. Onoue,Satoshi Kuwabara,Masahiro Mori,Masahiro Iijima,K. Ohyama,Masayuki Baba,M. Tomiyama,K. Nishiyama,Tsugio Akutsu,Kazumasa Yokoyama,K. Kanai,I. N. van Schaik,Filip Eftimov,Nicolette C. Notermans,Nora A. Visser,C. G. Faber,Janneke G. J. Hoeijmakers,Konrad Rejdak,U. Chyrchel-Paszkiewicz,C. Casanovas Pons,M. Alberti Aguiló,Josep Gamez,Maria Salvado Figueras,C. Marquez Infante,S. Benitez Rivero,Michael P. Lunn,Jasper M. Morrow,David Gosal,T. Lavin,I. Melamed,Alessandro Testori,Senda Ajroud-Driss,Daniela M. Menichella,Ericka Simpson,E. Chi-Ho Lai,Mazen M. Dimachkie,Richard J. Barohn,Said R. Beydoun,H. Johl,Dale J. Lange,Alexander Shtilbans,S. Muley,Shafeeq Ladha,Miriam Freimer,John T. Kissel,Norman Latov,Russell L. Chin,Eroboghene E. Ubogu,S. Mumfrey,T. Rao,P. MacDonald,Khema Sharma,Ginna Gonzalez,Jeffrey A. Allen,David Walk,Lisa D. Hobson-Webb,Karissa L. Gable +149 more
TL;DR: This study, which is to the authors' knowledge, the largest trial of CIDP to date and the first to study two administrations of immunoglobulins and two doses, showed that both doses of SCIg IgPro20 were efficacious and well tolerated, suggesting thatSCIg can be used as a maintenance treatment for C IDP.
Journal ArticleDOI
Autoantibodies to nodal isoforms of neurofascin in chronic inflammatory demyelinating polyneuropathy.
Emilien Delmont,Constance Manso,Luis Querol,Andrea Cortese,Angela Berardinelli,Alessandro Lozza,Maya Belghazi,Pauline Malissart,Pierre Labauge,Guillaume Taieb,Nobuhiro Yuki,Isabel Illa,Shahram Attarian,Jérôme Devaux +13 more
TL;DR: The data demonstrate that the pathogenic mechanisms responsible for chronic inflammatory demyelination polyneuropathy are broad and may include dysfunctions at the nodes of Ranvier in a subgroup of patients and that autoantibody depletion and recovery of conduction block and distal motor amplitude suggest a nodo-paranodopathy.