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Daniela Parolaro
Researcher at University of Insubria
Publications - 110
Citations - 8329
Daniela Parolaro is an academic researcher from University of Insubria. The author has contributed to research in topics: Cannabinoid receptor & Cannabinoid. The author has an hindex of 53, co-authored 110 publications receiving 7467 citations.
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Journal ArticleDOI
The endocannabinoid system and psychiatric disorders.
TL;DR: SR141716A and cannabidiol show the most constant antipsychotic properties in dopamine- and glutamate-based models of schizophrenia, with profiles similar to an atypical antipsychotics drug.
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Chronic exposure to morphine, cocaine or ethanol in rats produced different effects in brain cannabinoid CB1 receptor binding and mRNA levels
TL;DR: The results showed that these three drugs produced different changes in CB(1) receptor binding and mRNA levels, a finding that precludes the existence of a common alteration of the endocannabinoid system during dependence states to these habit-forming drugs.
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The depressive phenotype induced in adult female rats by adolescent exposure to THC is associated with cognitive impairment and altered neuroplasticity in the prefrontal cortex.
Tiziana Rubino,Natalia Realini,Daniela Braida,Tiziana Alberio,Valeria Capurro,Daniela Viganò,C. Guidali,Mariaelvina Sala,Mauro Fasano,Daniela Parolaro +9 more
TL;DR: To correlate memory impairment to altered neuroplasticity, level of marker proteins was investigated in the hippocampus and prefrontal cortex, the most relevant areas for learning and memory and revealed the presence of cognitive impairment in THC-induced depressive phenotype.
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Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain.
M. Valenti,Daniela Viganò,M. G. Casico,Tiziana Rubino,Luca Steardo,Daniela Parolaro,V. Di Marzo +6 more
TL;DR: The levels of the two major endocannabinoids, anandamide and 2-arachidonoyl-glycerol (2-AG), in four areas of the rat brain, change dramatically between the light and dark phases of the day, suggesting that the levels might be under the control of endogenous factors known to undergo diurnal variations.
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Endocannabinoids in the immune system and cancer.
TL;DR: Further investigations are needed to elucidate the function of endocannabinoids as immunosuppressant and antiproliferative/cytotoxic agents and argue in favor of the therapeutic potential of these compounds in immune disorders and cancer.