D
Daniela Parolaro
Researcher at University of Insubria
Publications - 110
Citations - 8329
Daniela Parolaro is an academic researcher from University of Insubria. The author has contributed to research in topics: Cannabinoid receptor & Cannabinoid. The author has an hindex of 53, co-authored 110 publications receiving 7467 citations.
Papers
More filters
Journal ArticleDOI
Long-lasting recovery of psychotic-like symptoms in isolation-reared rats after chronic but not acute treatment with the cannabinoid antagonist AM251.
TL;DR: Interestingly, the behavioural recovery due to chronic AM251 administration persisted until 10 d after discontinuing the treatment, indicating a long-lasting effect of the cannabinoid antagonist on psychotic-like symptoms.
Journal ArticleDOI
The psychoactive ingredient of marijuana induces behavioural sensitization
TL;DR: Challenge with Δ9‐tetrahydrocannabinol in pre‐exposed animals elicited a complex behavioural syndrome mainly characterized by oral stereotyped items, suggesting that cannabinoids could trigger neurobiological alteration not dissimilar from those observed with more harmful abused drugs.
Journal ArticleDOI
Binding of δ9‐tetrahydrocannabinol and diazepam to human serum albumin
Gabriella Fanali,Yu Cao,Paolo Ascenzi,Viviana Trezza,Tiziana Rubino,Daniela Parolaro,Mauro Fasano +6 more
TL;DR: The observed allosteric effect(s) suggests that the primary binding site of THC is the FA2 cleft that positively modulates heme affinity, which could account for drug delivery to the liver through receptor‐ mediated endocytosis.
Journal ArticleDOI
Endocannabinoids and Drug Dependence
TL;DR: This review will discuss the latest advances on the mechanisms of cannabinoid dependence and the possible role of the endocannabinoid system in the treatment of addiction, not only to marijuana but also to the other common illicit drugs.
Journal ArticleDOI
Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice
Erica Zamberletti,Marina Gabaglio,Fabiana Piscitelli,James Brodie,Marie Woolley-Roberts,Isabella Barbiero,Marco Tramarin,Giorgio Binelli,Nicoletta Landsberger,Charlotte Kilstrup-Nielsen,Tiziana Rubino,V. Di Marzo,Daniela Parolaro +12 more
TL;DR: CBDV administration exerts an enduring rescue of memory deficits in Mecp2 mutant mice, an effect that is associated with the normalization of BDNF, IGF-1 and rpS6 phosphorylation levels as well as CB1 and CB2 receptor expression.