Daniela Parolaro

TL;DR: It is suggested that voluntary chronic intake of opioids or cannabinoids induces reciprocal but differential regulation of MORs and CB1Rs density and activity in brain structures underlying drug‐taking and drug‐seeking behaviour, which could represent long‐term neuroadaptations contributing to the development of drug addiction and dependence.

TL;DR: This review describes the available data on the investigation of the presence of alterations of the EC system as well as the effects of its pharmacological manipulations in animal models of ASD-like behaviors.

TL;DR: It is demonstrated that adolescent THC administration is associated with persistent neuroinflammation within the PFC and evidence is provided for a causal association between microglial activation and the development long-term cognitive deficits induced by adolescent THC treatment.

TL;DR: This review updates the biochemical and molecular underpinnings of opioid and cannabinoid interaction, both within the central nervous system and periphery, and could pave the way for new and promising therapeutic approaches.

TL;DR: Chronic THC exposure induced increases in the ERK cascade (ERK, pCREB, and Fos B) in the prefrontal cortex and hippocampus, suggesting that different neuronal circuits seem to be involved in the early and late phase of exposure.