Daniela Parolaro

TL;DR: The results reveal a direct relationship between drug tolerance and changes in control of instrumental performance by establishing a central role for eCB LTD in habit expression and in vivo modulation of small-conductance calcium activated potassium channel activity in the DLS, which potentiates eCB signaling.

TL;DR: The ability of CBD to modulate tumour angiogenesis is evaluated and it is found that it effectively inhibits the growth of different types of tumours in vitro and in vivo and down‐regulates some pro‐angiogenic signals produced by glioma cells.

TL;DR: It is shown that the type 1 cannabinoid receptor (CB1) interacts physically with G-protein-associated sorting protein 1 (GASP1), a protein that sorts receptors in lysosomal compartments destined for degradation, which suggests that GASP 1 is a key regulator of the fate of CB1 after agonist exposure in the nervous system and critically determines analgesic tolerance to cannabinoids.

TL;DR: The results support CBD exploitation as an effective anti-cancer drug in the management of gliomas and show that this cannabinoid affects multiple tumoral features and molecular pathways.

TL;DR: This study demonstrates that adolescent THC exposure might have different behavioral outcomes in animals previously exposed to early-life stress compared with non-stressed controls.