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Danielle J. Ingle
Researcher at University of Melbourne
Publications - 42
Citations - 1127
Danielle J. Ingle is an academic researcher from University of Melbourne. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 33 publications receiving 674 citations. Previous affiliations of Danielle J. Ingle include Australian National University.
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Journal ArticleDOI
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
Jaclyn S. Pearson,Cristina Giogha,Sabrina Mühlen,Ueli Nachbur,Chi L.L. Pham,Ying Zhang,Joanne M Hildebrand,Clare V. Oates,Tania Wong Fok Lung,Danielle J. Ingle,Laura F. Dagley,Aleksandra Bankovacki,Emma J. Petrie,Gunnar N. Schroeder,Valerie F. Crepin,Gad Frankel,Seth L. Masters,James E Vince,James M. Murphy,Margaret Sunde,Andrew I. Webb,John Silke,Elizabeth L. Hartland +22 more
TL;DR: The activity of EspL defines a family of T3SS cysteine protease effectors found in a range of bacteria and reveals a mechanism by which gastrointestinal pathogens directly target RHIM-dependent inflammatory and necroptotic signalling pathways.
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Are Escherichia coli pathotypes still relevant in the era of whole-genome sequencing?
Roy M. Robins-Browne,Kathryn E. Holt,Danielle J. Ingle,Dianna M Hocking,Ji Yang,Marija Tauschek +5 more
TL;DR: A typing scheme for E.coli based on genome sequences that includes elements of both the core and accessory genomes, should reduce typing anomalies and promote understanding of how different varieties of E. coli spread and cause disease.
Journal ArticleDOI
In silico serotyping of E. coli from short read data identifies limited novel O-loci but extensive diversity of O:H serotype combinations within and between pathogenic lineages
Danielle J. Ingle,Mary Valcanis,Alex Kuzevski,Marija Tauschek,Michael Inouye,Timothy P. Stinear,Myron M. Levine,Roy M. Robins-Browne,Roy M. Robins-Browne,Kathryn E. Holt +9 more
TL;DR: The approach bypasses the need for de novo genome assembly by directly screening WGS reads against a curated database of alleles linked to known and novel E. coli O-groups and H-types (the EcOH database) using the software package srst2.
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Dynamics of antimicrobial resistance in intestinal Escherichia coli from children in community settings in South Asia and sub-Saharan Africa.
TL;DR: Genomic analysis of atypical enteropathogenic Escherichia coli strains isolated from children younger than five years old in South Asia and sub-Saharan Africa uncovers high antibiotic resistance prevalence, which is correlated with antibiotic use.
Journal ArticleDOI
Co-circulation of Multidrug-resistant Shigella Among Men Who Have Sex With Men in Australia
Danielle J. Ingle,Danielle J. Ingle,Marion Easton,Mary Valcanis,Torsten Seemann,Jason C Kwong,Nicola Stephens,Glen P. Carter,Anders Gonçalves da Silva,James Adamopoulos,Sarah L. Baines,Kathryn E. Holt,Kathryn E. Holt,Eric P F Chow,Christopher K Fairley,Marcus Y Chen,Martyn D. Kirk,Benjamin P Howden,Deborah A Williamson +18 more
TL;DR: Current data highlight the ongoing public health threat posed by resistant Shigella, both in Australia and globally, andUrgent multidisciplinary public health measures are required to interrupt transmission and prevent infection.