D
Danielle M Dunlea
Researcher at Royal College of Surgeons in Ireland
Publications - 8
Citations - 577
Danielle M Dunlea is an academic researcher from Royal College of Surgeons in Ireland. The author has contributed to research in topics: Alpha 1-antitrypsin deficiency & Ataluren. The author has an hindex of 6, co-authored 7 publications receiving 273 citations.
Papers
More filters
Journal ArticleDOI
Characterization of the Inflammatory Response to Severe COVID-19 Illness.
Oliver J. McElvaney,Natalie L McEvoy,Oisín F. McElvaney,Tomás P. Carroll,Mark P Murphy,Danielle M Dunlea,Orna Ní Choileáin,Jennifer Clarke,Eoin O'Connor,Grace Hogan,Daniel Ryan,Imran Sulaiman,Cedric Gunaratnam,P. Branagan,Michael Emmet O'Brien,Ross K. Morgan,Richard W. Costello,Killian Hurley,Seán Walsh,Eoghan de Barra,Cora McNally,Samuel J. McConkey,Fiona Boland,Sinead Galvin,Fiona Kiernan,James O'Rourke,R. Dwyer,Michael Power,Pierce Geoghegan,Caroline Larkin,Ruth Aoibheann O’Leary,James Freeman,Alan Gaffney,Brian Marsh,Gerard F. Curley,Noel G. McElvaney +35 more
TL;DR: The COVID-19 cytokinemia is distinct from that of other types of pneumonia, leading to organ failure and ICU need, and Cytokine ratios may predict outcomes in this population.
Journal ArticleDOI
Glycosylation Repurposes Alpha-1 Antitrypsin for Resolution of Community-acquired Pneumonia.
Cormac McCarthy,Danielle M Dunlea,Radka Saldova,Michael Henry,Paula Meleady,Oliver J. McElvaney,Brian Marsh,Pauline M. Rudd,Emer P. Reeves,Noel G. McElvaney +9 more
TL;DR: Altered AAT glycan signatures during the time course of acute infection and resolution of CAP are investigated, and the impact of altered N-glycan structures on the immune-regulatory effector function of AAT is determined.
Journal ArticleDOI
The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals.
TL;DR: Principally, AAT is a serine protease inhibitor; however, over the past number of years, the assessment of AAT as simply an antiprotease has evolved, and it is now recognized that AAT has significant anti-inflammatory properties affecting a wide range of cells, including the circulating neutrophil.
Journal ArticleDOI
Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function
Emer P. Reeves,Cormac McCarthy,Oliver J. McElvaney,Maya Sakthi N Vijayan,Michelle M. White,Danielle M Dunlea,Kerstin Pohl,Noreen Lacey,Noel G. McElvaney +8 more
TL;DR: The use of nebulised hypertonic saline (HTS) treatments has been shown to improve mucus clearance in CF and impact positively upon exacerbations, quality of life, and lung function and several mechanisms of HTS likely improve outcome, resulting in clinically relevant enhancement in disease parameters related to increase in mucociliary clearance.
Journal ArticleDOI
Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity.
Emer P. Reeves,Danielle M Dunlea,Karen McQuillan,Ciara A. O’Dwyer,Tomás P. Carroll,Radka Saldova,Prithvi Reddy Akepati,Mark R. Wormald,Oliver J. McElvaney,Vipatsorn Shutchaidat,Michael Henry,Paula Meleady,Joanne Keenan,Derek C. Liberti,Darrell N. Kotton,Pauline M. Rudd,Andrew A. Wilson,Noel G. McElvaney +17 more
TL;DR: Results support the rationale for treatment with pharmacological agents that augment levels of functional Q0bolton-AAT protein, thus offering a potential therapeutic option for AATD patients with rare mutations of similar theratype.