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Samuel J. McConkey
Researcher at Royal College of Surgeons in Ireland
Publications - 75
Citations - 3564
Samuel J. McConkey is an academic researcher from Royal College of Surgeons in Ireland. The author has contributed to research in topics: Population & Hepatitis B. The author has an hindex of 27, co-authored 70 publications receiving 3065 citations. Previous affiliations of Samuel J. McConkey include Washington University in St. Louis & University of Medicine and Health Sciences.
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Journal ArticleDOI
Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans.
Samuel J. McConkey,William H. H. Reece,Vasee S. Moorthy,Daniel P. Webster,Susanna Dunachie,G.A. Butcher,Jenni M. Vuola,Tom Blanchard,Philip Gothard,Kate E. Watkins,Carolyn M. Hannan,Simone Everaere,Karen Brown,Kent E. Kester,James F. Cummings,Jackie Williams,D. Gray Heppner,Ansar A. Pathan,Katie L. Flanagan,Nirmalan Arulanantham,M. Roberts,Michael Roy,Geoffrey L. Smith,Joerg Schneider,Tim E. A. Peto,Robert E. Sinden,Sarah C. Gilbert,Adrian V. S. Hill +27 more
TL;DR: It is shown that a heterologous prime-boost vaccination regime of DNA either intramuscularly or epidermally, followed by intradermal recombinant modified vaccinia virus Ankara (MVA), induces high frequencies of interferon-γ-secreting, antigen-specific T-cell responses in humans to a pre-erythrocytic malaria antigen, thrombospondin-related adhesion protein (TRAP).
Journal ArticleDOI
Characterization of the Inflammatory Response to Severe COVID-19 Illness.
Oliver J. McElvaney,Natalie L McEvoy,Oisín F. McElvaney,Tomás P. Carroll,Mark P Murphy,Danielle M Dunlea,Orna Ní Choileáin,Jennifer Clarke,Eoin O'Connor,Grace Hogan,Daniel Ryan,Imran Sulaiman,Cedric Gunaratnam,P. Branagan,Michael Emmet O'Brien,Ross K. Morgan,Richard W. Costello,Killian Hurley,Seán Walsh,Eoghan de Barra,Cora McNally,Samuel J. McConkey,Fiona Boland,Sinead Galvin,Fiona Kiernan,James O'Rourke,R. Dwyer,Michael Power,Pierce Geoghegan,Caroline Larkin,Ruth Aoibheann O’Leary,James Freeman,Alan Gaffney,Brian Marsh,Gerard F. Curley,Noel G. McElvaney +35 more
TL;DR: The COVID-19 cytokinemia is distinct from that of other types of pneumonia, leading to organ failure and ICU need, and Cytokine ratios may predict outcomes in this population.
Journal ArticleDOI
Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara
Daniel P. Webster,Susanna Dunachie,Jenni M. Vuola,Tamara Berthoud,Sheila M. Keating,Stephen M. Laidlaw,Samuel J. McConkey,Ian D. Poulton,Laura Andrews,Rikke Fredslund Andersen,Philip Bejon,G.A. Butcher,Robert E. Sinden,Michael A. Skinner,Sarah C. Gilbert,Adrian V. S. Hill +15 more
TL;DR: It is reported that substitution of plasmid DNA as the priming vector with a specific attenuated recombinant fowlpox virus, FP9, vaccine in such prime-boost regimes can elicit complete sterile protection that can last for 20 months.
Journal ArticleDOI
Assessment, Diagnosis, and Treatment of HIV-Associated Neurocognitive Disorder: A Consensus Report of the Mind Exchange Program
Andrea Antinori,Gabriele Arendt,Igor Grant,Scott Letendre,Jose A. Muñoz-Moreno,Christian Eggers,Bruce J. Brew,Marie-Josée Brouillette,Francisco Bernal-Cano,Adriana Carvalhal,Paulo Pereira Christo,Paola Cinque,Lucette A. Cysique,Ronald J. Ellis,Ian P. Everall,Jacques Gasnault,Ingo Husstedt,Volkan Korten,Ladislav Machala,Mark Obermann,Sílvia Ouakinin,Daniel Podzamczer,Peter Portegies,Simon Rackstraw,Sean B. Rourke,Lorraine Sherr,Adrian Streinu-Cercel,Alan Winston,Valerie Wojna,Yazdan Yazdanpannah,Gordon Arbess,Jean-Guy Baril,Josip Begovac,Colm Bergin,Paolo Bonfanti,Stefano Bonora,Kees Brinkman,Ana Canestri,Graźyna Cholewińska-Szymańska,Michal Chowers,John M. Cooney,Marcelo Corti,Colin P. Doherty,Daniel Elbirt,Stefan Esser,Eric Florence,Gilles Force,John Gill,Jean-Christophe Goffard,Thomas Harrer,Patrick C.K. Li,Linos Van de Kerckhove,Gaby Knecht,Shuzo Matsushita,Raimonda Matulionyte,Samuel J. McConkey,Antoine Mouglignier,Shinichi Oka,Augusto Penalva,Klaris Riesenberg,Helen Sambatakou,Valerio Tozzi,Matteo Vassallo,Peter Wetterberg,Alicia Wiercińska Drapato +64 more
TL;DR: The Mind Exchange program provides practical guidance in the diagnosis, monitoring, and treatment of HAND and identifies and develops practical answers to key clinical questions in HAND management.
Journal ArticleDOI
Durable Human Memory T Cells Quantifiable by Cultured Enzyme-Linked Immunospot Assays Are Induced by Heterologous Prime Boost Immunization and Correlate with Protection against Malaria
Sheila M. Keating,Philip Bejon,Tamara Berthoud,Jenni M. Vuola,Stephen Todryk,Daniel P. Webster,Susanna Dunachie,Vasee S. Moorthy,Samuel J. McConkey,Sarah C. Gilbert,Adrian V. S. Hill,Adrian V. S. Hill +11 more
TL;DR: This cultured assay identifies long-lasting protective T cell responses and therefore offers an attractive option for assessments of vaccine immunogenicity, despite a correlation between the peak ex vivo response and magnitude of memory responses 6 mo later.