M
Mark P Murphy
Researcher at Royal College of Surgeons in Ireland
Publications - 25
Citations - 522
Mark P Murphy is an academic researcher from Royal College of Surgeons in Ireland. The author has contributed to research in topics: Medicine & Alpha 1-antitrypsin deficiency. The author has an hindex of 3, co-authored 8 publications receiving 219 citations.
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Journal ArticleDOI
Characterization of the Inflammatory Response to Severe COVID-19 Illness.
Oliver J. McElvaney,Natalie L McEvoy,Oisín F. McElvaney,Tomás P. Carroll,Mark P Murphy,Danielle M Dunlea,Orna Ní Choileáin,Jennifer Clarke,Eoin O'Connor,Grace Hogan,Daniel Ryan,Imran Sulaiman,Cedric Gunaratnam,P. Branagan,Michael Emmet O'Brien,Ross K. Morgan,Richard W. Costello,Killian Hurley,Seán Walsh,Eoghan de Barra,Cora McNally,Samuel J. McConkey,Fiona Boland,Sinead Galvin,Fiona Kiernan,James O'Rourke,R. Dwyer,Michael Power,Pierce Geoghegan,Caroline Larkin,Ruth Aoibheann O’Leary,James Freeman,Alan Gaffney,Brian Marsh,Gerard F. Curley,Noel G. McElvaney +35 more
TL;DR: The COVID-19 cytokinemia is distinct from that of other types of pneumonia, leading to organ failure and ICU need, and Cytokine ratios may predict outcomes in this population.
Journal ArticleDOI
Activation of complement component 3 is associated with airways disease and pulmonary emphysema in alpha-1 antitrypsin deficiency.
Michael Emmet O'Brien,Laura T. Fee,Niall Browne,Tomás P. Carroll,Paula Meleady,Michael Henry,Karen McQuillan,Mark P Murphy,Mark Logan,Cormac McCarthy,Oliver J. McElvaney,Emer P. Reeves,Noel G. McElvaney +12 more
TL;DR: The association between plasma C3D levels and pulmonary disease severity, that decrease in response to AAT augmentation therapy, supports the exploration of C3d as a candidate biomarker of therapeutic efficacy in AATD.
Journal ArticleDOI
A randomized, double-blind, placebo-controlled trial of intravenous alpha-1 antitrypsin for ARDS secondary to COVID-19
Oliver J. McElvaney,Natalie L McEvoy,Fiona Boland,Oisín F. McElvaney,Grace Hogan,Kathleen J. Donnelly,Oisin Friel,Emmett Browne,D. Fraughen,Mark P Murphy,Jennifer Clarke,Orna Ni Choileain,Eoin O'Connor,R. McGuinness,Maria Boylan,Alan L. Kelly,John C Hayden,Ann M Collins,Ailbhe Cullen,D Hyland,Tomás P. Carroll,Pierce Geoghegan,John G. Laffey,Martina Hennessey,Ignacio Martin-Loeches,Noel G. McElvaney,Gerard F. Curley +26 more
TL;DR: In this article , the results of a phase 2, multicenter, randomized, double-blind, placebo-controlled trial of intravenous (IV) plasma-purified alpha-1 antitrypsin (AAT) for moderate to severe ARDS secondary to severe coronavirus disease 2019 (COVID-19) secondary to acute respiratory distress syndrome (ARDS).
Journal ArticleDOI
α1 Antitrypsin therapy modulates the neutrophil membrane proteome and secretome.
Mark P Murphy,Thomas McEnery,Karen McQuillan,Oisín F. McElvaney,Oliver J. McElvaney,Sarah Landers,Orla Coleman,Anchalin Bussayajirapong,Padraig Hawkins,Michael Henry,Paula Meleady,Emer P. Reeves,Noel G. McElvaney +12 more
TL;DR: Results provide strong insight into the mechanism of neutrophil driven airways disease associated with AATD and Therapeutic AAT augmentation modified the membrane proteome to that of a typical COPD cell, with implications for clinical practice.
Journal ArticleDOI
Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications
Oisín F. McElvaney,Takanori Asakura,Suzanne L Meinig,Jose Torres-Castillo,Robert S. Hagan,C. Gabillard,Mark P Murphy,Leigh B. Thorne,Alain C. Borczuk,Emer P. Reeves,Ross E. Zumwalt,Yu Mikami,Tomás P. Carroll,Kenichi Okuda,Grace Hogan,Oliver J. McElvaney,Jennifer Clarke,Natalie L McEvoy,Patrick W. G. Mallon,Cormac McCarthy,Ger Curley,Matthew C. Wolfgang,Richard C. Boucher,Noel G. McElvaney +23 more
TL;DR: In this paper , the authors investigated the protease-anti-protease balance in the circulation and pulmonary compartments in SARS-CoV-2 acute respiratory distress syndrome (ARDS) compared to non-SARS-CVC-2 ARDS (nsARDS).