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Danielle M. Grace
Researcher at Cold Spring Harbor Laboratory
Publications - 2
Citations - 158
Danielle M. Grace is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: PTEN & Prostate cancer. The author has an hindex of 1, co-authored 2 publications receiving 144 citations.
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Journal ArticleDOI
Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression
Muhan Chen,Christopher P. Pratt,Martha E. Zeeman,Nikolaus Schultz,Barry S. Taylor,Audrey K. O’Neill,Mireia Castillo-Martin,Dawid G. Nowak,Adam Naguib,Danielle M. Grace,Jernej Murn,Nicholas Navin,Gurinder S. Atwal,Chris Sander,William L. Gerald,Carlos Cordon-Cardo,Alexandra C. Newton,Brett S. Carver,Lloyd C. Trotman +18 more
TL;DR: The AKT-inactivating phosphatase PHLPP1 is identified as a prostate tumor suppressor and it is shown that Phlpp1-loss causes neoplasia and, on partial Pten-loss, carcinoma in mouse prostate.
Proceedings ArticleDOI
Abstract 2405: Identification of PHLPP as a tumour suppressor reveals the role of pathway feedback compensation in PTEN-mutant prostate cancer progression
Muhan Chen,Christopher P. Pratt,Martha E. Zeeman,N. Schultz,Barry S. Taylor,Audrey K. O’Neill,Mireia Castillo-Martin,Dawid G. Nowak,Adam Naguib,Danielle M. Grace,Jernej Murn,Chris Sander,William L. Gerald,Carlos Cordon-Cardo,Alexandra C. Newton,Brett S. Carver,Lloyd C. Trotman +16 more
TL;DR: It is demonstrated how the p53-response can antagonise co-deletion of PTEN and PHLPP to form a barrier against prostate cancer progression to emphasise the need for careful evaluation of PI 3-Kinase target therapy effects in prostate cancer and highlight the value of genetically engineered mouse models.