D
Danilo Toni
Researcher at Sapienza University of Rome
Publications - 52
Citations - 17537
Danilo Toni is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 14, co-authored 14 publications receiving 15782 citations. Previous affiliations of Danilo Toni include University of British Columbia.
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Journal ArticleDOI
Thrombolysis with Alteplase 3 to 4.5 Hours After Acute Ischemic Stroke
Werner Hacke,Markku Kaste,Erich Bluhmki,Miroslav Brozman,Antoni Dávalos,Donata Guidetti,Vincent Larrue,Kennedy R. Lees,Zakaria Medeghri,Thomas Machnig,Dietmar Schneider,Rüdiger von Kummer,Nils Wahlgren,Danilo Toni +13 more
TL;DR: As compared with placebo, intravenous alteplase administered between 3 and 4.5 hours after the onset of symptoms significantly improved clinical outcomes in patients with acute ischemic stroke; altePlase was more frequently associated with symptomatic intracranial hemorrhage.
Journal ArticleDOI
Intravenous Thrombolysis With Recombinant Tissue Plasminogen Activator for Acute Hemispheric Stroke: The European Cooperative Acute Stroke Study (ECASS)
Werner Hacke,Markku Kaste,Cesare Fieschi,Danilo Toni,Emmanuel Lesaffre,von Kummer R,Gudrun Boysen,Erich Bluhmki,Höxter G,Mahagne Mh +9 more
TL;DR: Intravenous thrombolysis in acute ischemic stroke is effective in improving some functional measures and neurologic outcome in a defined subgroup of stroke patients with moderate to severe neurologic deficit and without extended infarct signs on the initial CT scan, however, the identification of this subgroup is difficult.
Journal ArticleDOI
Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials.
Kennedy R. Lees,Erich Bluhmki,Rüdiger von Kummer,Thomas G. Brott,Danilo Toni,James C. Grotta,Gregory W. Albers,Markku Kaste,John R. Marler,Scott Hamilton,Barbara C. Tilley,Stephen M. Davis,Geoffrey A. Donnan,Werner Hacke +13 more
TL;DR: Patients with ischaemic stroke selected by clinical symptoms and CT benefit from intravenous alteplase when treated up to 4.5 h should be taken to shorten delay in initiation of treatment to increase benefit to a maximum.
Journal ArticleDOI
Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study
Nils Wahlgren,Niaz Ahmed,Antoni Dávalos,Gary A. Ford,Martin Grond,Werner Hacke,Michael G. Hennerici,Markku Kaste,Sonja Kuelkens,Vincent Larrue,Kennedy R. Lees,Risto O. Roine,Lauri Soinne,Danilo Toni,Geert Vanhooren +14 more
TL;DR: These data confirm that intravenous alteplase is safe and effective in routine clinical use when used within 3 h of stroke onset, even by centres with little previous experience of thrombolytic therapy for acute stroke.
Journal ArticleDOI
Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
Ralph L. Sacco,Hans-Christoph Diener,Salim Yusuf,Daniel Cotton,Stephanie Ôunpuu,William A. Lawton,Yuko Y. Palesch,Renee H Martin,Gregory W. Albers,Philip M.W. Bath,Natan M. Bornstein,Bernard P.L. Chan,Sien-Tsong Chen,Luís Cunha,Björn Dahlöf,Jacques De Keyser,Geoffrey A. Donnan,Conrado J. Estol,Philip B. Gorelick,Vivian Gu,Karin Hermansson,Lutz Hilbrich,Markku Kaste,Chuanzhen Lu,Thomas Machnig,Prem Pais,Robin S. Roberts,Skvortsova Vi,Philip Teal,Danilo Toni,Cam VanderMaelen,Thor Voigt,Michael A. Weber,Byung-Woo Yoon +33 more
TL;DR: The trial did not meet the predefined criteria for noninferiority but showed similar rates of recurrent stroke with ASA-ERDP and with clopidogrel, and there is no evidence that either of the two treatments was superior to the other in the prevention of recurrent strokes.