D
Daphne L. Davis
Researcher at University of Texas Southwestern Medical Center
Publications - 13
Citations - 3922
Daphne L. Davis is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Gene & Isozyme. The author has an hindex of 13, co-authored 13 publications receiving 3828 citations.
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Journal ArticleDOI
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.
TL;DR: The structure of the sterol 26-hydroxylase cDNA reveals it to be a mitochondrial cytochrome P-450, and blotting experiments revealed that the mRNA for this enzyme is expressed in many tissues and that it is encoded by a low copy number gene in the rabbit genome.
Cloning, structure and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase
TL;DR: In this article, the authors used protein sequencing and molecular cloning techniques to isolate and characterize a cDNA encoding the rabbit mitochondrial sterol 26-hydroxylase, which catalyzes the first step in the oxidation of the side chain of sterol intermediates in the biosynthesis of bile acids.
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Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3
Wayne M. Geissler,Daphne L. Davis,Ling Wu,Karen D. Bradshaw,S. Patel,Berenice B. Mendonca,Keith O. Elliston,Jean D. Wilson,David W. Russell,Stefan Andersson +9 more
TL;DR: Four substitution and two splice junction mutations were identified in the 17βHSD3 genes of five unrelated male pseudohermaphrodites that severely compromised the activity of the 17 β–HSD type 3 isozyme.
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Molecular genetics of steroid 5α-reductase 2 deficiency
Anice E. Thigpen,Daphne L. Davis,Athena Milatovich,Berenice B. Mendonca,Julianne Imperato-McGinley,Jim E. Griffin,Uta Francke,Jean D. Wilson,David W. Russell +8 more
TL;DR: Molecular analysis of the SRD5A2 gene resulted in the identification of 18 mutations in 11 homozygote, 6 compound heterozygotes, and 4 inferred compoundheterozygotes from 23 families with 5 alpha-reductase deficiency, suggesting that the carrier frequency of mutations in the 5alpha- reductase type 2 gene may be higher than previously thought.
Journal ArticleDOI
Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease.
Kenneth D.R. Setchell,Margrit Schwarz,Nancy C. O'Connell,Erik G. Lund,Daphne L. Davis,Richard Lathe,Henry R. Thompson,R. Weslie Tyson,Ronald J. Sokol,David W. Russell +9 more
TL;DR: The findings indicate the quantitative importance of the acidic pathway in early life in humans and define a further inborn error in bile acid synthesis as a metabolic cause of severe cholestatic liver disease.