D
Daphne Lelieveld
Researcher at Utrecht University
Publications - 12
Citations - 1316
Daphne Lelieveld is an academic researcher from Utrecht University. The author has contributed to research in topics: Spindle apparatus & Histone code. The author has an hindex of 8, co-authored 12 publications receiving 830 citations. Previous affiliations of Daphne Lelieveld include University Medical Center Utrecht.
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Journal ArticleDOI
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity
Norman Sachs,Joep de Ligt,Oded Kopper,Ewa Gogola,Gergana Bounova,Fleur Weeber,Anjali Vanita Balgobind,Karin Wind,Ana Gracanin,Harry Begthel,Jeroen Korving,Ruben van Boxtel,Alexandra A. Duarte,Daphne Lelieveld,Arne Van Hoeck,Robert F Ernst,Francis Blokzijl,Isaac J. Nijman,Marlous Hoogstraat,Marieke van der Ven,David A. Egan,Vittoria Zinzalla,Jürgen Moll,Sylvia F. Boj,Emile E. Voest,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Paul J. van Diest,Sven Rottenberg,Sven Rottenberg,Robert G.J. Vries,Edwin Cuppen,Hans Clevers +32 more
TL;DR: This study describes a representative collection of well-characterized BC organoids available for cancer research and drug development, as well as a strategy to assess in vitro drug response in a personalized fashion.
Journal ArticleDOI
Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C
Rachel Ulferts,S. Matthijn de Boer,Lonneke van der Linden,Lisa Bauer,Heyrhyoung Lyoo,Maria J. Maté,Maria J. Maté,Julie Lichière,Julie Lichière,Bruno Canard,Bruno Canard,Daphne Lelieveld,Wienand A. Omta,David A. Egan,Bruno Coutard,Bruno Coutard,Frank J. M. van Kuppeveld +16 more
TL;DR: Dibucaine bound to CV-B3 protein 2C in vitro, whereas binding to a 2C protein carrying the resistance mutations was reduced, providing an explanation for how resistance is acquired.
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An Image-Based miRNA Screen Identifies miRNA-135s As Regulators of CNS Axon Growth and Regeneration by Targeting Krüppel-like Factor 4.
Eljo Y. van Battum,Marieke G. Verhagen,Vamshidhar R. Vangoor,Yuki Fujita,Alwin A.H.A. Derijck,Eoghan O'Duibhir,Giuliano Giuliani,Thijs de Gunst,Youri Adolfs,Daphne Lelieveld,David A. Egan,Roel Q.J. Schaapveld,Toshihide Yamashita,R. Jeroen Pasterkamp +13 more
TL;DR: One of the first miRNome-wide functional miRNA screens is performed to identify miRNAs with robust effects on axon growth and show that intravitreal application of these mi RNAs facilitates CNS axon regeneration after nerve injury in adult mice, and identifies a novel neuronal role for the miR-135–KLF4 pathway.
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Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation
Roy G.H.P. van Heesbeen,Jonne A. Raaijmakers,Marvin E. Tanenbaum,Vincentius A. Halim,Vincentius A. Halim,Daphne Lelieveld,Cor Lieftink,Albert J. R. Heck,David A. Egan,René H. Medema +9 more
TL;DR: A novel function for astral MTs in force generation on spindle poles and how proteins involved in regulating microtubule length can contribute to bipolar spindle assembly are suggested.
Journal ArticleDOI
The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression
Ingrid T. G. W. Bijsmans,Chiara Guercini,José M. Ramos Pittol,Wienand A. Omta,Alexandra Milona,Daphne Lelieveld,David A. Egan,Roberto Pellicciari,Antimo Gioiello,Saskia W.C. van Mil +9 more
TL;DR: It is shown that separation between metabolic and anti-inflammatory functions of FXR can be achieved and that MF-bound FXR inhibits NF-κB subunit p65 recruitment to the DNA of pro-inflammatory genes CXCL2 and IL8.