R
Roberto Pellicciari
Researcher at University of Perugia
Publications - 358
Citations - 15591
Roberto Pellicciari is an academic researcher from University of Perugia. The author has contributed to research in topics: Metabotropic glutamate receptor & Bile acid. The author has an hindex of 55, co-authored 352 publications receiving 14034 citations. Previous affiliations of Roberto Pellicciari include École Polytechnique Fédérale de Lausanne & G. D. Searle & Company.
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Journal ArticleDOI
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Charles Thomas,Antimo Gioiello,Lilia G. Noriega,Lilia G. Noriega,Axelle Strehle,Julien Oury,Giovanni Rizzo,Antonio Macchiarulo,Hiroyasu Yamamoto,Hiroyasu Yamamoto,Chikage Mataki,Chikage Mataki,Mark Pruzanski,Roberto Pellicciari,Johan Auwerx,Johan Auwerx,Kristina Schoonjans,Kristina Schoonjans +17 more
TL;DR: It is shown here that TGR5 signaling induces intestinal glucagon-like peptide-1 (GLP-1) release, leading to improved liver and pancreatic function and enhanced glucose tolerance in obese mice, and suggested that pharmacological targeting of T GR5 may constitute a promising incretin-based strategy for the treatment of diabesity and associated metabolic disorders.
Journal ArticleDOI
Targeting bile-acid signalling for metabolic diseases
TL;DR: How the signalling functions of bile acids can be exploited in the development of drugs for obesity, type 2 diabetes, hypertriglyceridaemia and atherosclerosis, as well as other associated chronic diseases such as non-alcoholic steatohepatitis are reviewed.
Journal ArticleDOI
Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
TL;DR: Pharmacological agents targeting specific KP enzymes can be used to normalize KP defects, show remarkable efficacy in animal models of central nervous system disorders, and offer novel therapeutic opportunities.
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TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading.
Thijs W.H. Pols,Mitsunori Nomura,Taoufiq Harach,Giuseppe Lo Sasso,Maaike H. Oosterveer,Charles Thomas,Giovanni Rizzo,Antimo Gioiello,Luciano Adorini,Roberto Pellicciari,Johan Auwerx,Kristina Schoonjans +11 more
TL;DR: It is demonstrated that activation of TGR5 in macrophages by 6α-ethyl-23(S)-methylcholic acid (6-EMCA, INT-777), a semisynthetic BA, inhibits proinflammatory cytokine production, an effect mediated by T GR5-induced cAMP signaling and subsequent NF-κB inhibition.
Journal ArticleDOI
Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Elisabet Wahlberg,Tobias Karlberg,Ekaterina Kouznetsova,Ekaterina Kouznetsova,N. Markova,N. Markova,Antonio Macchiarulo,Ann-Gerd Thorsell,Ewa Pol,Åsa Frostell,T. Ekblad,Delal Öncü,Björn Kull,Graeme M. Robertson,Roberto Pellicciari,Herwig Schüler,J. Weigelt +16 more
TL;DR: Evaluated small-molecule inhibitors of poly-ADP-ribose polymerase (PARP) family proteins showed that the majority of PARP inhibitors bind multiple targets, providing insight into the design of new inhibitors.