J
Jonne A. Raaijmakers
Researcher at Netherlands Cancer Institute
Publications - 31
Citations - 1932
Jonne A. Raaijmakers is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Microtubule & Kinetochore. The author has an hindex of 18, co-authored 29 publications receiving 1601 citations. Previous affiliations of Jonne A. Raaijmakers include Utrecht University.
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Journal ArticleDOI
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).
Pascale F. Dijkers,René H. Medema,Cornelieke E.G.M. Pals,Lolita Banerji,N.S.B. Thomas,Eric Lam,Boudewijn M.T. Burgering,Jonne A. Raaijmakers,Jan-Willem J. Lammers,Leo Koenderman,P. J. Coffer +10 more
TL;DR: Observations indicate that inhibition of p27KIP1transcription through PI3K-induced FKHR-L1 phosphorylation provides a novel mechanism of regulating cytokine-mediated survival and proliferation.
Journal ArticleDOI
Systematic dissection of dynein regulators in mitosis
Jonne A. Raaijmakers,Jonne A. Raaijmakers,Marvin E. Tanenbaum,Marvin E. Tanenbaum,René H. Medema,René H. Medema +5 more
TL;DR: A comprehensive survey of the roles of dynein subunits and adaptors in mitosis reveals that dyne in forms distinct complexes requiring specific recruiters and activators to promote orderly progression through mitosis.
Journal ArticleDOI
Switching Polo-like kinase-1 on and off in time and space
TL;DR: Current knowledge on the mechanisms that enforce the temporal and spatial control of Plk1 activity are reviewed, and how this results in coordinated phosphorylation of its many different substrates are reviewed.
Journal ArticleDOI
p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies
Mar Soto,Jonne A. Raaijmakers,Bjorn Bakker,Diana C.J. Spierings,Peter M. Lansdorp,Floris Foijer,René H. Medema +6 more
TL;DR: It is shown that p53 is activated only in a subset of the cells with altered chromosome content, and it is demonstrated that propagation of structural aneuploidies (gain or loss of part of a chromosome) induced by segregation errors is limited to p53-deficient cells.
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RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment.
TL;DR: A high-throughput RNAi screen is performed to identify additional factors involved in kinetochore-microtubule attachment, and identifies RAMA1 as a novel regulator of this process and suggests that RAMA 1 may have a direct role in mediating kinetchore- microtubule interactions.