D
Darcy B. Wilson
Researcher at Torrey Pines Institute for Molecular Studies
Publications - 96
Citations - 6694
Darcy B. Wilson is an academic researcher from Torrey Pines Institute for Molecular Studies. The author has contributed to research in topics: Antigen & Lymphocyte. The author has an hindex of 40, co-authored 96 publications receiving 6599 citations. Previous affiliations of Darcy B. Wilson include Wistar Institute & La Jolla Institute for Allergy and Immunology.
Papers
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Journal ArticleDOI
Transfer of a functional human immune system to mice with severe combined immunodeficiency
TL;DR: The results suggest that xenogeneic transplantation of human lymphoid cells into SCID mice may provide a useful model for the study of normal human immune function, the response of the immune system to pathogenic agents and early events in lym-phomagenesis.
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Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.
TL;DR: Preursors of cytotoxic cells thus have the same high frequency of cells reactive to alloantigens of the major histocompatibility complex as found among proliferating cells in graft- vs-host reactions and mixed lymphocyte interactions.
Journal ArticleDOI
Human immunodeficiency virus infection of human-PBL-SCID mice.
Donald E. Mosier,Richard J. Gulizia,Stephen M. Baird,Darcy B. Wilson,Deborah H. Spector,Stephen A. Spector +5 more
TL;DR: HIV-1 infection affected the concentration of human immunoglobulin and the number of CD4+ T cells in the mice and support the use of the hu-PBL-SCID mouse for studies of the pathogenesis and treatment of AIDS.
Journal ArticleDOI
Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation
Michelle Krogsgaard,Nelida Prado,Erin J. Adams,Xiaolin He,Dar Chone Chow,Darcy B. Wilson,K. Christopher Garcia,Mark M. Davis +7 more
TL;DR: Thermodynamics of TCR binding to a series of peptide-MHC ligands, three of which are more stimulatory than their stability of binding would predict, is analyzed, finding that during T CR binding these outliers show anomalously large changes in heat capacity, an indicator of conformational change or flexibility in a binding interaction.
Patent
Human immune system in non-human animal
Darcy B. Wilson,Donald E. Mosier +1 more
TL;DR: In this paper, the immune system of a donor is induced in and thrives in vivo and expresses the immune response of the donor animal in a recipient non-human animal of a different species than the donor.