E
Erin J. Adams
Researcher at University of Chicago
Publications - 124
Citations - 8051
Erin J. Adams is an academic researcher from University of Chicago. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 46, co-authored 119 publications receiving 7119 citations. Previous affiliations of Erin J. Adams include Oregon Health & Science University & University of California, Berkeley.
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Journal ArticleDOI
Analysis of a successful immune response against hepatitis C virus
Stewart Cooper,Ann L. Erickson,Erin J. Adams,Joe Kansopon,Amy J. Weiner,David Y. Chien,Michael Houghton,Peter Parham,Christopher M. Walker +8 more
TL;DR: It is suggested that CD8+CTL are better correlated with protection against HCV infection than antibodies, and every specificity shown during acute hepatitis persisted in normal liver tissue more than 1 yr after resolution.
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Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset
Christelle Harly,Christelle Harly,Christelle Harly,Yves Guillaume,Steven Nedellec,Steven Nedellec,Steven Nedellec,Cassie-Marie Peigné,Cassie-Marie Peigné,Cassie-Marie Peigné,Hannu Mönkkönen,Jukka Mönkkönen,Jianqiang Li,Jürgen Kuball,Erin J. Adams,Sonia Netzer,Julie Déchanet-Merville,Alexandra Leger,Alexandra Leger,Alexandra Leger,Thomas Herrmann,Richard Breathnach,Richard Breathnach,Richard Breathnach,Daniel Olive,Marc Bonneville,Marc Bonneville,Marc Bonneville,Emmanuel Scotet,Emmanuel Scotet,Emmanuel Scotet +30 more
TL;DR: A novel role played by B7-like molecules in human γδ T-cell antigenic activation is demonstrated and paves the way for new strategies to improve the efficiency of immunotherapies using Vγ9Vδ2 T cells.
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The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells.
Andrew Sandstrom,Cassie Marie Peigné,Alexandra Leger,Alexandra Leger,Alexandra Leger,James E. Crooks,Fabienne Konczak,Fabienne Konczak,Fabienne Konczak,Marie Claude Gesnel,Marie Claude Gesnel,Marie Claude Gesnel,Richard Breathnach,Richard Breathnach,Richard Breathnach,Marc Bonneville,Marc Bonneville,Marc Bonneville,Emmanuel Scotet,Emmanuel Scotet,Emmanuel Scotet,Erin J. Adams +21 more
TL;DR: It is demonstrated that internal sensing of changes in pAg metabolite concentrations by BTN3A1 molecules is a critical step in Vγ9Vδ2 T cell detection of infection and tumorigenesis.
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MAIT cells are imprinted by the microbiota in early life and promote tissue repair
Michael G. Constantinides,Verena M. Link,Samira Tamoutounour,Andrea C. Wong,P. Juliana Perez-Chaparro,Seong-Ji Han,Y. Erin Chen,Kelin Li,Sepideh Farhat,Antonin Weckel,Siddharth R. Krishnamurthy,Ivan Vujkovic-Cvijin,Jonathan L. Linehan,Nicolas Bouladoux,E. Dean Merrill,Sobhan Roy,Daniel J. Cua,Erin J. Adams,Avinash Bhandoola,Tiffany C. Scharschmidt,Jeffrey Aubé,Michael A. Fischbach,Yasmine Belkaid +22 more
TL;DR: How the microbiota can direct immune cell development and subsequent function at mucosal sites by secreting compounds that act like self-antigens is highlighted by highlighting how the bacteria and fungi can direct tissue repair functions by promoting the maturation and homeostasis of the immune system.
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The origins of HLA-A,B,C polymorphism.
TL;DR: The tremendous diversity of HLA-A,B,C make these genes wonderful tools for those interested in the evolution of human populations and their immune relationship to diverse pathogens.