R
Richard S. Blumberg
Researcher at Brigham and Women's Hospital
Publications - 462
Citations - 43223
Richard S. Blumberg is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 104, co-authored 443 publications receiving 38798 citations. Previous affiliations of Richard S. Blumberg include Emory University & Harvard University.
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Journal ArticleDOI
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
Lauren W. Collison,Creg J. Workman,Timothy T. Kuo,Kelli L. Boyd,Yao Wang,Kate M. Vignali,Richard L. Cross,David Sehy,Richard S. Blumberg,Dario A. A. Vignali +9 more
TL;DR: IL-35 is identified as a novel inhibitory cytokine that may be specifically produced by Treg cells and is required for maximal suppressive activity.
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Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function
Torsten Olszak,Dingding An,Sebastian Zeissig,Miguel Pinilla Vera,Julia Richter,Andre Franke,Jonathan N. Glickman,Reiner Siebert,Rebecca M. Baron,Dennis L. Kasper,Richard S. Blumberg +10 more
TL;DR: It is shown that in germ-free (GF) mice, invariant natural killer T (iNKT) cells accumulate in the colonic lamina propria and lung, resulting in increased morbidity in models of IBD and allergic asthma as compared with that of specific pathogen-free mice.
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The immunology of mucosal models of inflammation.
TL;DR: This work analyzes the immunology of the IBDs through the lens of the murine models, first by drawing attention to their common features and then by considering individual models at a level of detail necessary to reveal their individual capacities to provide insight into IBD pathogenesis.
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XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
Arthur Kaser,Ann-Hwee Lee,Andre Franke,Jonathan N. Glickman,Sebastian Zeissig,Herbert Tilg,Edward E. S. Nieuwenhuis,Darren E. Higgins,Stefan Schreiber,Laurie H. Glimcher,Richard S. Blumberg +10 more
TL;DR: It is reported that XBP1 deletion in intestinal epithelial cells (IECs) results in spontaneous enteritis and increased susceptibility to induced colitis secondary to both Paneth cell dysfunction and an epithelium that is overly reactive to inducers of IBD such as bacterial products (flagellin) and TNFalpha.
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How colonization by microbiota in early life shapes the immune system
TL;DR: The role of early-life education of the immune system during this “window of opportunity,” when disruption of optimal host-commensal interactions can lead to persistent and in some cases irreversible defects in the development and training of specific immune subsets is discussed.