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Darleen A. Sandoval
Researcher at University of Michigan
Publications - 137
Citations - 9873
Darleen A. Sandoval is an academic researcher from University of Michigan. The author has contributed to research in topics: Glucose homeostasis & Sleeve gastrectomy. The author has an hindex of 47, co-authored 137 publications receiving 8108 citations. Previous affiliations of Darleen A. Sandoval include Arizona State University & Vanderbilt University.
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Journal ArticleDOI
Vertical sleeve gastrectomy improves ventilatory drive through a leptin-dependent mechanism.
TL;DR: Clinically, these data downgrade the relative contribution of physical, mechanical load in the pathogenesis of OHS, and instead point to physiological components of obesity, including alterations in leptin signaling, as key drivers in OHS.
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Leptin responses to antecedent exercise and hypoglycemia in healthy and type 1 diabetes mellitus men and women
TL;DR: Plasma leptin levels decrease in response to hypoglycemia in healthy but not type 1 diabetes mellitus subjects, however, T1DM patients do have increased basal leptin levels compared to healthy man.
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The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism
Deanna M. Arble,Jenna Holland,Nickki Ottaway,Joyce Sorrell,Joshua W. Pressler,Rachel Morano,Rachel Morano,Stephen C. Woods,Stephen C. Woods,Randy J. Seeley,Randy J. Seeley,James P. Herman,James P. Herman,Darleen A. Sandoval,Darleen A. Sandoval,Diego Perez-Tilve +15 more
TL;DR: It is suggested that Mc4r signaling plays a protective role in minimizing glucose fluctuations due to circadian rhythms and environmental light cues and demonstrate a previously undiscovered connection between circadian biology and glucose metabolism mediated through the melanocortin system.
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Metabolic consequences of exercise-associated autonomic failure.
TL;DR: Type I diabetes mellitus patients who tightly control blood glucose levels toward normal have increased frequency of hypoglycemia, a major barrier to physical activity, and the hypothesis that dysfunctional autonomic regulation of metabolism after recent bouts of exercise contributes to exercise-induced hyp glucosecemia in these patients is presented.
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Female rats are relatively more sensitive to reduced lipid versus reduced carbohydrate availability
TL;DR: The data collectively suggest that males are relatively more sensitive to glucose deprivation and females are relatively less sensitive to lipid deprivation.