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Darleen A. Sandoval
Researcher at University of Michigan
Publications - 137
Citations - 9873
Darleen A. Sandoval is an academic researcher from University of Michigan. The author has contributed to research in topics: Glucose homeostasis & Sleeve gastrectomy. The author has an hindex of 47, co-authored 137 publications receiving 8108 citations. Previous affiliations of Darleen A. Sandoval include Arizona State University & Vanderbilt University.
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Journal ArticleDOI
Bariatric surgery emphasizes biological sex differences in rodent hepatic lipid handling.
Bernadette E. Grayson,Ruth Gutierrez-Aguilar,Joyce Sorrell,Emily K. Matter,Michelle R. Adams,Philip N. Howles,Rebekah Karns,Randy J. Seeley,Darleen A. Sandoval +8 more
TL;DR: Taken together, although both males and females lose weight and improve plasma lipids, there are large-scale sex differences in hepatic gene expression and consequently hepatic lipid metabolism after VSG.
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Differences in acute anorectic effects of long-acting GLP-1 receptor agonists in rats.
TL;DR: It is shown here that the glucose lowering properties of acute administration of GLP-1R agonists are not accounted for by their central effects, and differing anorectic potencies in the CNS may account for some of their clinical differences.
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Differing physiological effects of epinephrine in type 1 diabetes and nondiabetic humans
Deanna L. Aftab Guy,Darleen A. Sandoval,M. A. Richardson,Donna B. Tate,Paul J. Flakoll,Stephen N. Davis,Stephen N. Davis +6 more
TL;DR: There is a spectrum of significant in vivo physiological differences of epinephrine action at the liver, muscle, adipose tissue, pancreas, and cardiovascular system between T1DM and healthy subjects.
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Physiological and molecular responses to bariatric surgery: markers or mechanisms underlying T2DM resolution?
TL;DR: Whether postprandial enhancement of gut peptide and bile acids levels, restructuring of microbial composition, and changes in GI function and morphology are necessary for the improvements in body mass and glucose homeostasis are explored.
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The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice.
Chelsea R. Hutch,Karen J. Roelofs,April Haller,Joyce Sorrell,Kyle Leix,David D. D’Alessio,Robert Augustin,Randy J. Seeley,Thomas Klein,Darleen A. Sandoval +9 more
TL;DR: Increases in pancreatic GLP-1 and GIP are necessary for the full effect of DPP-4 inhibitors on glucose tolerance, and genetically engineered mouse lines in which the preproglucagon gene is absent in the entire body or is expressed exclusively in the intestine are used.