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Darleen A. Sandoval
Researcher at University of Michigan
Publications - 137
Citations - 9873
Darleen A. Sandoval is an academic researcher from University of Michigan. The author has contributed to research in topics: Glucose homeostasis & Sleeve gastrectomy. The author has an hindex of 47, co-authored 137 publications receiving 8108 citations. Previous affiliations of Darleen A. Sandoval include Arizona State University & Vanderbilt University.
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Journal ArticleDOI
Identification of optimal reference genes for RT-qPCR in the rat hypothalamus and intestine for the study of obesity
Bailing Li,Emily K. Matter,H T Hoppert,Bernadette E. Grayson,Randy J. Seeley,Darleen A. Sandoval +5 more
TL;DR: Gene expression levels of reference genes commonly used in obesity-related studies, such as ACTB or RPS18, are altered by changes in acute or chronic energy status, demonstrating the importance of using reference genes that are stable in expression across experimental conditions when studying the rat hypothalamus and intestine.
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Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents.
Teayoun Kim,Cassie Holleman,Shelly Nason,Deanna M. Arble,Nickki Ottaway,Joseph Chabenne,Christine Loyd,Jeong-a Kim,Darleen A. Sandoval,Daniel J. Drucker,Richard D. DiMarchi,Richard D. DiMarchi,Diego Perez-Tilve,Kirk M. Habegger +13 more
TL;DR: Investigation of the effect of glucagon agonism on insulin action and glucose homeostasis reveals that GCGR agonism enhances glucose tolerance, in part, by augmenting insulin action, with implications for the use of GC GR agonism in therapeutic strategies for diabetes.
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Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice.
Wenwen Cheng,Ermelinda Ndoka,Chelsea R. Hutch,Karen J. Roelofs,Andrew MacKinnon,Basma Khoury,Jack Magrisso,Ki-Suk Kim,Christopher J. Rhodes,David P. Olson,Randy J. Seeley,Darleen A. Sandoval,Martin G. Myers +12 more
TL;DR: It is found that the cre-dependent ablation of NTS Ppgflox early in development or in adult mice failed to alter energy balance, suggesting the importance of pathways independent of NTS GLP1 for the long-term control of food intake.
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Neuroscience: Weight loss through smoking
TL;DR: The identification of the molecular target in the brain for the appetite-suppressant effects of nicotine is a first step towards finding healthy alternatives to smoking for weight management.
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Cortisol Acts Through Central Mechanisms to Blunt Counterregulatory Responses to Hypoglycemia in Conscious Rats
TL;DR: It is concluded that cortisol can act directly on the central nervous system to blunt counterregulatory responses to subsequent hypoglycemia in the conscious rat.