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Darleen A. Sandoval
Researcher at University of Michigan
Publications - 137
Citations - 9873
Darleen A. Sandoval is an academic researcher from University of Michigan. The author has contributed to research in topics: Glucose homeostasis & Sleeve gastrectomy. The author has an hindex of 47, co-authored 137 publications receiving 8108 citations. Previous affiliations of Darleen A. Sandoval include Arizona State University & Vanderbilt University.
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Journal ArticleDOI
Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin.
Jonathan N. Flak,Paulette B. Goforth,James M. Dell’Orco,Paul V. Sabatini,Chien Li,Nadejda Bozadjieva,Matthew J. Sorensen,Alec C. Valenta,Alan C. Rupp,Alison H. Affinati,Corentin Cras-Méneur,Ahsan Ansari,Jamie Sacksner,Nandan Kodur,Darleen A. Sandoval,Robert T. Kennedy,David P. Olson,Martin G. Myers +17 more
TL;DR: VMNCCKBR cells represent a specialized subset of VMN cells that function to elevate glucose that insulin-independently modulate the homeostatic setpoint for blood glucose, consistent with a role for the brain in the insulin-independent control of glucose homeostasis.
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Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?
Rohit Kohli,Andriy Myronovych,Brandon K. Tan,Rosa Maria Salazar-Gonzalez,Lili Miles,Wujuan Zhang,Melissa Oehrle,Darleen A. Sandoval,Karen K. Ryan,Randy J. Seeley,Kenneth D.R. Setchell +10 more
TL;DR: Key bile acid signaling elements that may provide potential therapeutic targets for ‘bariatric-mimetic technologies' that could produce benefits similar to bariatric surgery - but without the surgery are described.
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Gender differences in the endocrine and metabolic responses to hypoxic exercise.
TL;DR: Although the women had greater baseline levels of cortisol and growth hormone, gender did not affect these hormones during H or exercise, and the endocrine response to hypoxia per se was not blunted in women as the authors had hypothesized, other mechanisms must be at play to cause the gender differences in metabolic substrates in response to Hypoxia.
Journal ArticleDOI
The Anorectic Effect of GLP-1 in Rats Is Nutrient Dependent
Darleen A. Sandoval,Jason G. Barrera,Margaret A. Stefater,Stephanie Sisley,Stephen C. Woods,David D. D’Alessio,Randy J. Seeley +6 more
TL;DR: It is found that fasting blunted the ability of 3rd cerebroventricularly (i3vt)-administered GLP-1 to reduce food intake, however, fasted animals maintained the anorexic response to melanotan II, a melanocortin receptor agonist, indicating a specific effect of fasting on GLp-1 action.
Journal ArticleDOI
Stimulation of both type I and type II corticosteroid receptors blunts counterregulatory responses to subsequent hypoglycemia in healthy man
Stephanie M. Gustavson,Darleen A. Sandoval,Andrew C. Ertl,Shichun Bao,Satish R. Raj,Stephen N. Davis +5 more
TL;DR: Levels of a wide spectrum of key counterregulatory mechanisms were blunted by antecedent pharmacological stimulation of either type I or type II corticosteroid receptors in healthy man.