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Darren J. Baker
Researcher at Mayo Clinic
Publications - 80
Citations - 15949
Darren J. Baker is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Aneuploidy. The author has an hindex of 39, co-authored 69 publications receiving 11756 citations.
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Journal ArticleDOI
Spartan deficiency causes genomic instability and progeroid phenotypes.
Reeja S. Maskey,Myoung Shin Kim,Darren J. Baker,Bennett G. Childs,Liviu Malureanu,Karthik B. Jeganathan,Yuka Machida,Jan M. van Deursen,Yuichi J. Machida +8 more
TL;DR: It is reported that Spartan insufficiency in mice causes chromosomal instability, cellular senescence and early onset of age-related phenotypes, and a link between Spartaninsufficiency and progeria is suggested and demonstrated and structural and numerical chromosome integrity is maintained.
Journal ArticleDOI
Aging-Associated Vascular Phenotype in Mutant Mice With Low Levels of BubR1
Takuya Matsumoto,Darren J. Baker,Livius V. d’Uscio,Gazi Mozammel,Zvonimir S. Katusic,Jan M. van Deursen +5 more
TL;DR: Findings demonstrate that BubR 1 insufficiency in mice results in phenotypic changes reminiscent of vascular aging in humans and suggest a role for BubR1 in suppressing the vascular aging process.
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Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice.
Petra Niessen,Sander S. Rensen,Jan M. van Deursen,Joris G. De Man,Ann De Laet,Jean-Marie Vanderwinden,Thilo Wedel,Darren J. Baker,Pieter A. Doevendans,Marten H. Hofker,Marion J.J. Gijbels,Guillaume J.J.M. van Eys +11 more
TL;DR: Smoothelin-A is essential for functional contractility of intestinal smooth muscle and is reminiscent of that seen in patients with chronic intestinal pseudo-obstruction, and experimental data indicate a role for smoothelins in smooth muscle contraction.
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Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans
Matthew J. Yousefzadeh,Marissa J. Schafer,Nicole Noren Hooten,Elizabeth J. Atkinson,Michele K. Evans,Darren J. Baker,Ellen Quarles,Paul D. Robbins,Warren C. Ladiges,Nathan K. LeBrasseur,Laura J. Niedernhofer +10 more
TL;DR: The conclusion that MCP‐1 can be used as a measure of mammalian biological age that is responsive to interventions that extend healthy aging is supported.
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Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism
Rafael Flores,Cheryl L. Clauson,Joonseok Cho,Byeong Chel Lee,Sara J. McGowan,Darren J. Baker,Laura J. Niedernhofer,Paul D. Robbins +7 more
TL;DR: The results suggest that NF‐κB activation with aging, at least in part, drives an increase in the percentage of MDSCs, a cell type able to suppress immune cell responses.