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Darren J. Baker
Researcher at Mayo Clinic
Publications - 80
Citations - 15949
Darren J. Baker is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Aneuploidy. The author has an hindex of 39, co-authored 69 publications receiving 11756 citations.
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Patent
Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
Darren J. Baker,Marco Demaria,Albert R. Davalos,Bennett G. Childs,Jan M. van Deursen,James L. Kirkland,Tamar Tchkonia,Yi Zhu,Nathaniel David,Remi-Martin Laberge,Judith Campisi +10 more
TL;DR: In this paper, a method and materials for treating arthritis by removing senescent cells in or around atherosclerotic plaques, thereby stabilizing the plaques and inhibiting rupture of the plaque and pathological sequelae that manifest as coronary artery disease.
Patent
Animal models for cancer and uses thereof
Judith Campisi,Judith Campisi,Jan M. van Deursen,James L. Kirkland,Tamar Tchkonia,Darren J. Baker,Marco Demaria +6 more
TL;DR: In this article, non-human animal cancer models are provided for identifying and characterizing agents useful for therapy and prophylaxis of cancers, including drugs useful for diminishing side effects related to cancer therapies and reducing metastatic disease.
Journal ArticleDOI
Erratum: Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency (Nature Cell Biology (2008) 10 (825-836))
Patent
Pharmaceutical Products and Drug Combinations for Treating Atherosclerosis by Stabilizing Atherosclerotic Plaques and Promoting Plaque Regression
Jan M. van Deursen,Bennett G. Childs,Darren J. Baker,James L. Kirkland,Tamar Tchkonia,Yi Zhu,Nathaniel David,Remi-Martin Laberge,Judith Campisi,Marco Demaria +9 more
TL;DR: In this article, the authors used senolytic agents that remove senescent cells that are present in or around atherosclerotic plaques to stabilize the plaques, inhibiting rupture and preventing pathological sequelae that manifest as coronary artery disease.
Journal ArticleDOI
Cellular senescence: beneficial, harmful, and highly complex
TL;DR: The contribution of cellular senescence to a diverse range of biological processes, including normal physiology, ageing, and pathology were long overlooked but have now taken centre stage as mentioned in this paper , and progress has been made in re-defining and identifying senescent cells, especially in slow-proliferating or terminally differentiated tissues, such as the brain and cardiovascular system.