Darren J. Baker

TL;DR: During embryonic development, it is found that Bub1b(H/H), but not Ercc1(-/Δ7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-type controls in the cerebral cortex, reaching a frequency as high as 40.3% for each chromosome tested.

TL;DR: The resident cells of the central nervous system are described, how they exhibit tendencies toward senescence with age and disease, and tools that will be useful to aid in senescent cell identification and characterization in this tissue are discussed.

TL;DR: It is demonstrated that BUBR1 allelic effects beyond protein level and aneuploidy contribute to disease heterogeneity in both MVA patients and heterozygous carriers of MVA mutations.

TL;DR: It is demonstrated that phosphorylation of p65 serine 467 augment NF-κB activity and exacerbates various deleterious effects of overnutrition in mice.

TL;DR: It is shown that HSPCs arrest at prometaphase and induce p53-dependent apoptosis upon prolonged treatment with anti-mitotic drugs, and hematopoiesis is impaired, manifested by loss of differentiation potential and engraftment ability, indicating a critical role of this checkpoint in H SPCs and he matopoiedis.