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Darren J. Gorman
Researcher at Columbia University
Publications - 3
Citations - 674
Darren J. Gorman is an academic researcher from Columbia University. The author has contributed to research in topics: Lipoprotein & Adipose tissue. The author has an hindex of 3, co-authored 3 publications receiving 552 citations.
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Journal ArticleDOI
Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity
Prabhakara R Nagareddy,Michael J Kraakman,Seth L. Masters,Roslynn A. Stirzaker,Darren J. Gorman,Ryan W. Grant,Dragana Dragoljevic,Eun Shil Hong,Ahmed Abdel-Latif,Susan S. Smyth,Sung Hee Choi,Judith Korner,Karin E. Bornfeldt,Edward A. Fisher,Vishwa Deep Dixit,Alan R. Tall,Ira J. Goldberg,Andrew J. Murphy,Andrew J. Murphy,Andrew J. Murphy +19 more
TL;DR: A positive feedback loop between ATMs and BM myeloid progenitors is uncovered and inhibition of TLR4 ligands or the NLRP3-IL-1β signaling axis could reduce AT inflammation and insulin resistance in obesity.
Journal ArticleDOI
Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice
Marit Westerterp,Andrew J. Murphy,Mi Wang,Tamara A. Pagler,Yuliya Vengrenyuk,Mojdeh S Kappus,Darren J. Gorman,Prabhakara R Nagareddy,Xuewei Zhu,Sandra Abramowicz,John S. Parks,Carrie L. Welch,Edward A. Fisher,Nan Wang,Laurent Yvan-Charvet,Alan R. Tall +15 more
TL;DR: This paper developed mice with efficient deletion of the ATP-binding cassette transporters A1 and G1 in macrophages (MAC-ABCDKO mice) but not in hematopoietic stem or progenitor populations.
Journal ArticleDOI
Pegylation of High-Density Lipoprotein Decreases Plasma Clearance and Enhances Antiatherogenic Activity
TL;DR: A novel method for effective monopegylation of apoAI in HDL particles, in which lipid binding seems to protect against pegylated of key functional residues, markedly increases its plasma half-life and enhances antiatherogenic properties in vivo.