L
Laurent Yvan-Charvet
Researcher at French Institute of Health and Medical Research
Publications - 98
Citations - 10140
Laurent Yvan-Charvet is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: ABCA1 & Cholesterol. The author has an hindex of 42, co-authored 90 publications receiving 8417 citations. Previous affiliations of Laurent Yvan-Charvet include University of Washington & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
Cholesterol, inflammation and innate immunity
TL;DR: Therapeutic interventions such as increased production or infusion of high-density lipoproteins may sever the links between cholesterol accumulation and inflammation, and have beneficial effects in patients with metabolic diseases.
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Cholesterol Efflux and Atheroprotection Advancing the Concept of Reverse Cholesterol Transport
Robert S. Rosenson,H. Bryan Brewer,W. Sean Davidson,Zahi A. Fayad,Valentin Fuster,James A. Goldstein,Marc K. Hellerstein,Xian-Cheng Jiang,Michael C. Phillips,Daniel J. Rader,Alan T. Remaley,George H. Rothblat,Alan R. Tall,Laurent Yvan-Charvet +13 more
TL;DR: High-density lipoprotein has been proposed to have several antiatherosclerotic properties, including the ability to mediate macrophage cholesterol efflux, antioxidant capacity, antiinflammatory properties, nitric oxide–promoting activity, and ability to transport proteins with their own intrinsic biological activities.
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ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation
Laurent Yvan-Charvet,Tamara A. Pagler,Emmanuel L. Gautier,Serine Avagyan,Read L. Siry,Seongah Han,Carrie L. Welch,Nan Wang,Gwendalyn J. Randolph,Hans Snoeck,Alan R. Tall +10 more
TL;DR: The findings indicate that ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of these populations with leukocytosis and accelerated atherosclerosis.
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Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses
TL;DR: These studies have shown that the traditional roles of HDL and ABC transporters in cholesterol efflux and reverse cholesterol transport are mechanistically linked to antiinflammatory and immunosuppressive functions of HDL.
Journal ArticleDOI
Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice.
Laurent Yvan-Charvet,Mollie Ranalletta,Nan Wang,Seongah Han,Naoki Terasaka,Rong Li,Carrie L. Welch,Alan R. Tall +7 more
TL;DR: The results suggest that the combined effects of ABCA1 and ABCG1 in mediating macrophage sterol efflux are central to the antiatherogenic properties of HDL.