S
Susan S. Smyth
Researcher at University of Kentucky
Publications - 61
Citations - 5649
Susan S. Smyth is an academic researcher from University of Kentucky. The author has contributed to research in topics: Platelet & Integrin. The author has an hindex of 39, co-authored 54 publications receiving 5073 citations. Previous affiliations of Susan S. Smyth include Lexington VA Medical Center & Veterans Health Administration.
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Journal ArticleDOI
Platelet functions beyond hemostasis
Susan S. Smyth,Rodger P. McEver,Andrew S. Weyrich,C. N. Morrell,Maureane Hoffman,Gowthami M. Arepally,Patricia A. French,Harold L. Dauerman,Richard C. Becker +8 more
TL;DR: The process of and factors mediating platelet–platelet and platelet-leukocyte interactions in inflammatory and immune responses are discussed, with the roles of P‐selectin, chemokines and Src family kinases being highlighted.
Journal ArticleDOI
Aspirin dose for the prevention of cardiovascular disease: a systematic review.
TL;DR: A systematic review of the English-language literature was undertaken using MEDLINE and EMBASE (searched through February 2007) and the search term aspirin or acetylsalicylic acid and dose as discussed by the authors.
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Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity
Prabhakara R Nagareddy,Michael J Kraakman,Seth L. Masters,Roslynn A. Stirzaker,Darren J. Gorman,Ryan W. Grant,Dragana Dragoljevic,Eun Shil Hong,Ahmed Abdel-Latif,Susan S. Smyth,Sung Hee Choi,Judith Korner,Karin E. Bornfeldt,Edward A. Fisher,Vishwa Deep Dixit,Alan R. Tall,Ira J. Goldberg,Andrew J. Murphy,Andrew J. Murphy,Andrew J. Murphy +19 more
TL;DR: A positive feedback loop between ATMs and BM myeloid progenitors is uncovered and inhibition of TLR4 ligands or the NLRP3-IL-1β signaling axis could reduce AT inflammation and insulin resistance in obesity.
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Rap1b is required for normal platelet function and hemostasis in mice
Magdalena Chrzanowska-Wodnicka,Susan S. Smyth,Simone M. Schoenwaelder,Thomas Fischer,Gilbert C. White +4 more
TL;DR: Genetic evidence is provided that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target.
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Increased mortality among patients taking digoxin—analysis from the AFFIRM study
Matthew G. Whitbeck,Richard Charnigo,Paul Khairy,Khaled M. Ziada,Alison L. Bailey,Milagros M. Zegarra,Jignesh Shah,Gustavo Morales,Tracy Macaulay,Vincent L. Sorrell,Charles L. Campbell,John C. Gurley,Paul Anaya,Hafez Nasr,Rong Bai,Luigi Di Biase,David C. Booth,Guillaume Jondeau,Andrea Natale,Denis Roy,Susan S. Smyth,David J. Moliterno,Claude S. Elayi +22 more
TL;DR: Findings call into question the widespread use of digoxin in patients with AF after correcting for clinical characteristics and comorbidities, regardless of gender or of the presence or absence of HF.