S
Srboljub M. Mijailovich
Researcher at Illinois Institute of Technology
Publications - 65
Citations - 4445
Srboljub M. Mijailovich is an academic researcher from Illinois Institute of Technology. The author has contributed to research in topics: Myosin & Myosin head. The author has an hindex of 26, co-authored 57 publications receiving 4086 citations. Previous affiliations of Srboljub M. Mijailovich include Steward Health Care System & Tufts University.
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Journal ArticleDOI
Mechanical behavior in living cells consistent with the tensegrity model
Ning Wang,Keiji Naruse,Dimitrije Stamenović,Jeffrey J. Fredberg,Srboljub M. Mijailovich,Iva Marija Tolić-Norrelykke,Thomas R. Polte,Robert Mannix,Donald E. Ingber +8 more
TL;DR: Findings suggest that tensegrity represents a unified model of cell mechanics that may help to explain how mechanical behaviors emerge through collective interactions among different cytoskeletal filaments and extracellular adhesions in living cells.
Journal ArticleDOI
Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells
Ning Wang,Iva Marija Tolić-Norrelykke,Jianxin Chen,Srboljub M. Mijailovich,James P. Butler,Jeffrey J. Fredberg,Dimitrije Stamenović +6 more
TL;DR: Data establish a strong association between stiffness of HASM cells and the level of tensile stress within the cytoskeleton, a hallmark of systems that secure shape stability mainly through the prestress.
Journal ArticleDOI
Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma
Steven S. An,Tony R. Bai,Jason H. T. Bates,Judith L. Black,Robert H. Brown,Vito Brusasco,Pasquale Chitano,Linhong Deng,Linhong Deng,Maria Dowell,David H. Eidelman,Ben Fabry,Nigel J. Fairbank,Lincoln E. Ford,Jeffrey J. Fredberg,William T. Gerthoffer,S. H. Gilbert,Reinoud Gosens,S. J. Gunst,Andrew J. Halayko,R. H. Ingram,Charles G. Irvin,Alan L. James,Luke J. Janssen,Gregory G. King,Darryl A. Knight,Anne-Marie Lauzon,O. J. Lakser,Mara S. Ludwig,Kenneth R. Lutchen,Geoffrey N. Maksym,James G. Martin,Thais Mauad,Brent E. McParland,Srboljub M. Mijailovich,Howard W. Mitchell,Richard W. Mitchell,Wayne Mitzner,Thomas M. Murphy,Peter D. Paré,Riccardo Pellegrino,Michael J. Sanderson,R. Robert Schellenberg,Chun Y. Seow,Paulo Sérgio Panse Silveira,Paul G. Smith,Julian Solway,Newman L. Stephens,Peter J. Sterk,Alastair G. Stewart,Dale D. Tang,Robert S. Tepper,Thai Tran,Lu Wang +53 more
TL;DR: A central role for airway smooth muscle in the pathogenesis of airway hyperresponsiveness in asthma is explored and an attempt is made to address a fundamental abnormality of asthma, that of exaggerated airway narrowing due to excessive shortening of ASM.
Journal ArticleDOI
Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm.
TL;DR: It is shown here that regulation of airway smooth muscle length corresponds to a dynamically equilibrated steady state, not the static mechanical equilibrium that had been previously assumed.
Journal ArticleDOI
Universal behavior of the osmotically compressed cell and its analogy to the colloidal glass transition
Enhua H. Zhou,Xavier Trepat,Chan Young Park,Guillaume Lenormand,Madavi Oliver,Srboljub M. Mijailovich,C. Corey Hardin,David A. Weitz,James P. Butler,Jeffrey J. Fredberg +9 more
TL;DR: This work provides a means to probe the physical nature of the cytoplasm under compression, and leads to results that are universal across cell type, which suggests that compression-induced weakening of the network is overwhelmed by crowding-induced stiffening of the Cy toplasm.