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Darryl C. DeVivo
Researcher at Columbia University
Publications - 32
Citations - 4342
Darryl C. DeVivo is an academic researcher from Columbia University. The author has contributed to research in topics: Cytochrome c oxidase & Mitochondrial DNA. The author has an hindex of 24, co-authored 32 publications receiving 4200 citations. Previous affiliations of Darryl C. DeVivo include NewYork–Presbyterian Hospital.
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Journal ArticleDOI
Mitochondrial DNA Deletions in Progressive External Ophthalmoplegia and Kearns-Sayre Syndrome
Carlos T. Moraes,Salvatore DiMauro,Massimo Zeviani,Anne Lombès,Sara Shanske,Armand F. Miranda,Hirofumi Nakase,Eduardo Bonilla,Lineu Cesar Werneck,Serenella Servidei,Ikuya Nonaka,Yasutoshi Koga,Alfred J. Spiro,A. Keith W. Brownell,Beny Schmidt,Donald L. Schotland,Mary L. Zupanc,Darryl C. DeVivo,Eric A. Schon,Lewis P. Rowland +19 more
TL;DR: It is concluded that deletions of muscle mitochondrial DNA are associated with ophthalmoplegia and may result in impaired mitochondrial function, however, the precise relation between clinical and biochemical phenotypes and deletions remains to be defined.
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MELAS: Clinical features, biochemistry, and molecular genetics
Emma Ciafaloni,Enzo Ricci,S. Shanske,Carlos T. Moraes,Gabriella Silvestri,Michio Hirano,Simonetta Simonetti,Corrado Angelini,M.A. Donati,C. Garcia,Andrea Martinuzzi,R. K. Mosewich,Serenella Servidei,Enrico Zammarchi,Eduardo Bonilla,Darryl C. DeVivo,Lewis P. Rowland,Eric A. Schon,Salvatore DiMauro +18 more
TL;DR: There was no clear correlation between percentage of mutant mitochondrial DNAs and severity of the biochemical defect, but there was a high concordance between clinical diagnosis of MELAS and transfer RNALeu(UUR) mutation.
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Cytochrome C oxidase deficiency in Leigh syndrome
Salvatore DiMauro,Serenella Servidei,Massimo Zeviani,Maja DiRocco,Darryl C. DeVivo,Stefano DiDonato,Graziella Uziel,Kenneth Berry,George E. Hoganson,Stanley D. Johnsen,Peter C. Johnson +10 more
TL;DR: The theory that COX deficiency is an important cause of Leigh syndrome is confirmed, with essentially normal amounts of cross‐reacting enzyme protein in various tissues from different patients.
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Andersen's syndrome : potassium-sensitive periodic paralysis, ventricular ectopy, and dysmorphic features
Rabi Tawil,Louis J. Ptáček,Steven G. Pavlakis,Darryl C. DeVivo,Audrey S. Penn,Coşkun Özdemir,Robert C. Griggs +6 more
TL;DR: The genetic defect in Andersen's syndrome is not genetically linked to other forms of potassium‐sensitive periodic paralysis and is probably distinct from the long QT syndrome locus.
Journal ArticleDOI
MELAS: An original case and clinical criteria for diagnosis
Michio Hirano,Enzo Ricci,M. Richard Koenigsberger,Richard Defendini,Steven G. Pavlakis,Darryl C. DeVivo,Salvatore DiMauro,Lewis P. Rowland +7 more
TL;DR: The full history and postmortem findings in one of the first identified cases of mitochondrial encephalomyopathy with stroke-like episodes (MELAS) are described and analysis of mitochondrial DNA (mtDNA) may point to the correct diagnosis.