David A. Powell

TL;DR: A copper-catalyzed amidation of allylic and benzylic C-H bonds with both primary and secondary sulfonamides is described, which is applicable to the coupling of a diverse set of hydrocarbon species with aryl, heteroaryl, and alkyl sulf onamides and is tolerant of a variety of functional groups.

TL;DR: The discovery of MK-8245 is found, a potent, liver-targeted SCD inhibitor with preclinical antidiabetic and antidyslipidemic efficacy with a significantly improved therapeutic window.

TL;DR: A room-temperature, copper-catalyzed amination of primary benzylic C-H bonds with primary and secondary sulfonamides with tolerant of substitution on both coupling partners is described.

TL;DR: Kinetic isotope studies support a mechanism involving a benzylic hydrogen abstraction and an inexpensive copper catalyst-oxidant system that is suitable for the coupling of a range ofbenzylic C-H bonds with various 1,3-dicarbonyl compounds.

TL;DR: Azetidine derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase relative to other known desaturases as mentioned in this paper, and are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, metabolic syndrome; insulin resistance, liver steatosis; and non-alcoholic steatohepatitis.