Kathryn Skorey

TL;DR: A Staphylococcus aureus antisense knockdown strategy is adapted to genetically identify the cell division Z ring components—FtsA, FtsZ, and FtsW—as β-lactam susceptibility determinants of methicillin-resistant S. aureUS to support a target-based approach to develop synergistic drug combinations to combat MRSA with improved efficacy and reduced potential for drug resistance.

TL;DR: Activity assays for tyrosine phosphatases include the determinations of the rate of dephosphorylation and calculations of kinetic constants such as k(cat) and K(M) that are commonly used to evaluate the efficiency of inhibitors.

TL;DR: The discovery of MK-8245 is found, a potent, liver-targeted SCD inhibitor with preclinical antidiabetic and antidyslipidemic efficacy with a significantly improved therapeutic window.

TL;DR: A series of potent and highly selective cyclooxygenase-2 inhibitors have been prepared by replacing the benzoyl group of indomethacin with a 4-bromobenzyl group and by extending the acetic acid side chain, showing anti-inflammatory activity in rats with no evidence of GI toxicity, even at high doses.

TL;DR: In this article, the crystal structures of protein tyrosine phosphatase 1B (PTP1B) in complex with first and second generation aryldifluoromethyl-phosphonic acid inhibitors were reported.