David Ahern

TL;DR: This work defines how the colonic mesenchyme remodels to fuel inflammation and barrier dysfunction in IBD.

TL;DR: A CyTOF-based comprehensive mapping of the immune cell subsets within atherosclerotic aortas from ApoE−/− mice offers tools for myeloid cell discrimination within the vascular compartment and it reveals that high fat feeding skews the myeloids cell repertoire toward inflammatory monocyte-macrophage populations rather than resident macrophage phenotypes and cDC2 during atherogenesis.

TL;DR: The current understanding of NK cell biology is outlined and how these cells may modulate disease pathogenesis in rheumatoid arthritis through interactions with other immune cells are outlined.

TL;DR: An epigenetic link between the histone H3K27me3 demethylases KDM6A/B and the coordination of a metabolic response is established and suggests a critical role of H 3K27 demethylase enzymes in maintaining Th17 functions by controlling metabolic switches.

TL;DR: It is indicated that blockade of NKG2D in a murine model and in human explants has beneficial therapeutic potential that merits further investigation in RA.