M
Moustafa Attar
Researcher at University of Oxford
Publications - 36
Citations - 2514
Moustafa Attar is an academic researcher from University of Oxford. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 13, co-authored 27 publications receiving 1487 citations. Previous affiliations of Moustafa Attar include Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Distinct fibroblast subsets drive inflammation and damage in arthritis.
Adam P. Croft,Joana Campos,Kathrin Jansen,Jason D. Turner,Jennifer L. Marshall,Moustafa Attar,Loriane Savary,Corinna Wehmeyer,Corinna Wehmeyer,Amy J. Naylor,Samuel Kemble,Jenefa Begum,Kerstin Dürholz,Kerstin Dürholz,Harris Perlman,Francesca Barone,Helen M. McGettrick,Douglas T. Fearon,Kevin Wei,Soumya Raychaudhuri,Ilya Korsunsky,Michael B. Brenner,Mark Coles,Stephen N. Sansom,Andrew Filer,Christopher D. Buckley +25 more
TL;DR: It is shown that deletion of fibroblast activation protein-α (FAPα)+ fibroblasts suppressed both inflammation and bone erosions in mouse models of resolving and persistent arthritis.
Journal ArticleDOI
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease
James Kinchen,Hannah Chen,Kaushal Parikh,Agne Antanaviciute,Marta Jagielowicz,David Fawkner-Corbett,Neil Ashley,Laura Cubitt,Esther Mellado-Gomez,Moustafa Attar,Eshita Sharma,Quin F. Wills,Rory Bowden,Felix Richter,David Ahern,Kamal D. Puri,Jill Henault,Francois Gervais,Hashem Koohy,Alison Simmons +19 more
TL;DR: This work defines how the colonic mesenchyme remodels to fuel inflammation and barrier dysfunction in IBD.
Journal ArticleDOI
Factors influencing success of clinical genome sequencing across a broad spectrum of disorders
Jenny C. Taylor,Jenny C. Taylor,Hilary C. Martin,Stefano Lise,John Broxholme,Jean-Baptiste Cazier,Andrew J. Rimmer,Alexander Kanapin,Gerton Lunter,Simon Fiddy,Chris Allan,A. Radu Aricescu,Moustafa Attar,Christian Babbs,Jennifer Becq,David Beeson,Celeste Bento,P Bignell,Edward Blair,Veronica J. Buckle,Katherine R. Bull,Katherine R. Bull,Ondrej Cais,Holger Cario,Helen Chapel,Richard R. Copley,Richard R. Copley,Richard J. Cornall,Jude Craft,Jude Craft,Karin Dahan,Emma E. Davenport,Calliope A. Dendrou,Olivier Devuyst,Aimee L. Fenwick,Jonathan Flint,Lars Fugger,Rodney D. Gilbert,Anne Goriely,Angie Green,Ingo H. Greger,Russell J. Grocock,Anja V. Gruszczyk,Robert W. Hastings,Edouard Hatton,Doug Higgs,Adrian V. S. Hill,Adrian V. S. Hill,Christopher Holmes,Christopher Holmes,Malcolm F. Howard,Malcolm F. Howard,Linda Hughes,Peter Humburg,David W. Johnson,Fredrik Karpe,Zoya Kingsbury,Usha Kini,Julian C. Knight,Jon P. Krohn,Sarah Lamble,Craig B. Langman,Lorne Lonie,Joshua Luck,Davis J. McCarthy,Simon J. McGowan,Mary Frances McMullin,Kerry A. Miller,Lisa Murray,Andrea H. Németh,M. Andrew Nesbit,David J. Nutt,Elizabeth Ormondroyd,Annette Bang Oturai,Alistair T. Pagnamenta,Alistair T. Pagnamenta,Smita Y. Patel,Melanie J. Percy,Nayia Petousi,Paolo Piazza,Sian E. Piret,Guadalupe Polanco-Echeverry,Niko Popitsch,Niko Popitsch,Fiona Powrie,Christopher W. Pugh,Lynn Quek,Peter A. Robbins,Kathryn J. H. Robson,Alexandra Russo,Natasha Sahgal,Pauline A. van Schouwenburg,Anna Schuh,Anna Schuh,Earl D. Silverman,Alison Simmons,Per Soelberg Sørensen,Elizabeth Sweeney,John Taylor,John Taylor,Rajesh V. Thakker,Ian Tomlinson,Ian Tomlinson,Amy Trebes,Stephen R.F. Twigg,Holm H. Uhlig,Paresh Vyas,Timothy J. Vyse,Steven A. Wall,Hugh Watkins,Michael P. Whyte,Lorna Witty,Ben Wright,Christopher Yau,David Buck,Sean Humphray,Peter J. Ratcliffe,John I. Bell,Andrew O.M. Wilkie,David Bentley,Peter Donnelly,Peter Donnelly,Gilean McVean +122 more
TL;DR: It is found that jointly calling variants across samples, filtering against both local and external databases, deploying multiple annotation tools and using familial transmission above biological plausibility contributed to accuracy.
Journal ArticleDOI
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis.
Stefano Alivernini,Lucy MacDonald,Aziza Elmesmari,Samuel Finlay,Barbara Tolusso,Maria Rita Gigante,Luca Petricca,Clara Di Mario,Laura Bui,Simone Perniola,Moustafa Attar,Marco Gessi,Anna Laura Fedele,Sabarinadh Chilaka,Domenico Somma,Stephen N. Sansom,Andrew Filer,Andrew Filer,Charles McSharry,Neal L. Millar,Kristina Kirschner,Alessandra Nerviani,Myles Lewis,Costantino Pitzalis,Andrew R. Clark,Gianfranco Ferraccioli,Irina A. Udalova,Christopher D. Buckley,Elisa Gremese,Elisa Gremese,Iain B. McInnes,Thomas D. Otto,Mariola Kurowska-Stolarska +32 more
TL;DR: Multiple subpopulations of synovial tissue macrophages with varied transcriptional, phenotypic and functional features may contribute to disease flare and tissue repair in patients with active rheumatoid arthritis and patients in clinical remission.
Journal ArticleDOI
Improved workflows for high throughput library preparation using the transposome-based nextera system
Sarah Lamble,Elizabeth M. Batty,Moustafa Attar,David Buck,Rory Bowden,Gerton Lunter,Derrick W. Crook,Bassam El-Fahmawi,Paolo Piazza +8 more
TL;DR: A modified protocol is produced which harnesses the full power of the Nextera kit and allows the reproducible construction of libraries on a high-throughput scale reducing the associated cost of the kit.